Protein Alignment MAN1 and Lemd2

DIOPT Version :9

• Sequence 1: NP_001286812.1
• Gene: MAN1 / 37838
• FlyBaseID: FBgn0034962
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: XP_038954742.1
• Gene: Lemd2 / 361807
• RGDID: 1305341
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 626
• Identity: 125/626 - (19%)
• Similarity: 209/626 - (33%)
• Gaps: 215/626 - (34%)

  Fly     9 LSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRKHTRADKLKKRSNKYVLYSKEQQESPPFPQYH 73
            |||.||.|:|...||...|:|:|||.|...|||:.....:|:            ..|.|     .
  Rat     4 LSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLR------------DDERP-----R 51

  Fly    74 QYHAPQPPQNYANGLDNNNDLDQTGGSSAYNRSLDES---DSSPLQLSASKMYAPPPVVASNYDG 135
            :...|:.|:                      |..:|:   :.:||:       |.|....
  Rat    52 EEARPRGPE----------------------RQREEARLREEAPLR-------ARPAAAV----- 82

  Fly   136 DCSPHSLGLNGKYLQPCSMPYAIDTSNNYGKPSGKAKLSDGGVVNRLLSFRDTTIQRKFNYPTGQ 200
               |.|    ..:|.|.:...|.||...||              |...|.....:.|..:||| .
  Rat    83 ---PRS----EPWLSPPAPSAASDTPGPYG--------------NFGASAAPWAVSRGLSYPT-H 125

  Fly   201 ASRIPLRKERLTRFALSDLKSFIRNPD-----------------IRPY----------------- 231
            ....|||:....|.:..|.:. .|.||                 .||:
  Rat   126 TGPGPLRRRASVRGSSEDDED-ARTPDRAAPGRARHWWVASSASARPHSALLGADTRPGLKGQRT 189

  Fly   232 ------------------VIPRVL----ISLFLIFLTIITVLYVGKRFEQSPIDKAALKYTLCNP 274
                              .:.|:|    :.|.|:||.|:.|........|...|...|....|.
  Rat   190 GSAGVVRARPEAGRRLERCLSRLLLWASLGLLLVFLAILWVKMGKPSAPQEAEDNMKLLPVDCE- 253

  Fly   275 NDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKD-----ANLSPALEIGEFVR--- 331
               :...|.....:|.:|   |::..||:..|..:|....|.:     :...|.||..|::.
  Rat   254 ---RKTDEFCQARQKAAL---LELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIAPRA 312

  Fly   332 --------EMVSNPKTHRGN------LHSNLMAAKYLITENPQWSIQVVDSTKHLGQTSHFELSE 382
                    :.|::..:.|..      |.||.....:|..|:|...:..||....|      |.:.
  Rat   313 ELTPSSTLQNVTSSSSSRFKAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCL------ESAR 371

  Fly   383 PNLPLKCIVLKKVTRFFTVIGALLLIVAGFLIVY---------VAVVIYRVKQKEALLAVDQFQK 438
            |.:.:.|    :::|      |||..|...||.:         :.::.||.::.|   ..:|...
  Rat   372 PRMGMGC----RLSR------ALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLE---EEEQAMY 423

  Fly   439 DIINELI------YLSSQSES---PEVVINQLQEKFLPAKKRSKLLSSWNKALKQLEKNDSRVLF 494
            :::.::|      |:..:.:.   |.|.|..:::..:|.:.|.::...|::|::.|..|:||:..
  Rat   424 EMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQT 488

  Fly   495 GMVNRDGKAMRTIAWNRNVDKKDVGLVKKWQSP-AFDNSNK 534
            ......|:.|               ||.:|..| :|.:|.:
  Rat   489 ESHRVAGEDM---------------LVWRWTKPSSFSDSER 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_001286812.1	LEM	4..47	CDD:128813	18/37 (49%)
		MSC	<381..509	CDD:286487	28/145 (19%)
		RRM_Man1	542..631	CDD:240732
Lemd2	XP_038954742.1	LEM	4..41	CDD:413420	18/36 (50%)
		MSC	<277..504	CDD:401378	49/260 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D593495at33208
OrthoFinder	1	1.000	-	-		FOG0004711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13428
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040