Protein Alignment MAN1 and Lemd2

DIOPT Version :9

• Sequence 1: NP_001286812.1
• Gene: MAN1 / 37838
• FlyBaseID: FBgn0034962
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_666187.2
• Gene: Lemd2 / 224640
• MGIID: 2385045
• Length: 511
• Species: Mus musculus
• Alignment Length: 614
• Identity: 126/614 - (20%)
• Similarity: 209/614 - (34%)
• Gaps: 194/614 - (31%)

  Fly     9 LSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRK-----------------HTRADKLKKRSNKY 56
            |||.||.|:|...||...|:|:|||.|...|||:                 ..|.|...:...:.
Mouse     4 LSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQ 68

  Fly    57 VLYSKEQQESP-------------PFPQYHQYHAPQPPQNYANGLDNNNDLDQTGGSS---AYNR 105
            ...::.::|:|             |:|.     :|.||...| ..|.:......|.|:   |.:|
Mouse    69 REEARLREEAPLRARPAASVLRSEPWPL-----SPSPPAPSA-ASDASGPYGNFGASASPWAASR 127

  Fly   106 SLD---ESDSSPLQLSAS-----------------------KMYAPPPVVASNYDGDCSPHSLGL 144
            .|.   .:...||:..||                       ..:|||...|       .||| .|
Mouse   128 GLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASA-------RPHS-AL 184

  Fly   145 NGKYLQPCSMPYAIDTSNNYGKPSGKAKLSDGGVVNRLLSFRDTTIQRKFNYPTGQASRIPLRKE 209
            .|...:|     .:..|......:|:.:...|..:.|.||
Mouse   185 LGADARP-----GLKGSRTGSAGAGRTRPEVGRWLERCLS------------------------- 219

  Fly   210 RLTRFALSDLKSFIRNPDIRPYVIPRVLISLFLIFLTIITVLYVGKRFEQSPIDKAALKYTLCNP 274
            ||..:|                     .:.|.|.||.|:.|........|...|...|....|..
Mouse   220 RLLLWA---------------------SLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCER 263

  Fly   275 NDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKD-----ANLSPALEIGEFVREMV 334
            ...:....|    :|.:|   |::..||:..|..:|....|.:     :...|.||..|::..:.
Mouse   264 KTDEFCQAK----QKAAL---LELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVT 321

  Fly   335 SNPKTH-----RGNLHSNLMAAKYLITENPQWSIQVVDSTKHLGQTSHFELSEPNLPLKCIVLKK 394
            |:|.:.     ...|.||.....:|..|:|......||....|      |.:.|.:.:.|    :
Mouse   322 SSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCL------ESARPRMGIGC----R 376

  Fly   395 VTRFFTVIGALLLIVAGFLIVY---------VAVVIYRVKQKEALLAVDQFQKDIINELI----- 445
            ::|      |||..|...||.:         :.::.||.::.|   ..:|...:::.::|
Mouse   377 LSR------ALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLE---EEEQAMYEMVKKIIDVVQD 432

  Fly   446 -YLSSQSES---PEVVINQLQEKFLPAKKRSKLLSSWNKALKQLEKNDSRVLFGMVNRDGKAMRT 506
             |:..:.:.   |.|.|..:::..:|.:.|.::...|::|::.|..|:||:........|:.|
Mouse   433 HYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDM-- 495

  Fly   507 IAWNRNVDKKDVGLVKKWQSP-AFDNSNK 534
                         ||.:|..| :|.:|.:
Mouse   496 -------------LVWRWTKPSSFSDSER 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_001286812.1	LEM	4..47	CDD:128813	19/54 (35%)
		MSC	<381..509	CDD:286487	28/145 (19%)
		RRM_Man1	542..631	CDD:240732
Lemd2	NP_666187.2	LEM	4..41	CDD:295412	18/36 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..110		21/97 (22%)
		Interaction with lamin A/C complexes. /evidence=ECO:0000250	80..112		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..206		17/90 (19%)
		MSC	<286..501	CDD:286487	49/248 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D593495at33208
OrthoFinder	1	1.000	-	-		FOG0004711
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2606
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.940