DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAN1 and lemd3

DIOPT Version :9

Sequence 1:	NP_001286812.1	Gene:	MAN1 / 37838	FlyBaseID:	FBgn0034962	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	XP_012813817.2	Gene:	lemd3 / 100038042	XenbaseID:	XB-GENE-486033	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	175/807 - (21%)
Similarity:	291/807 - (36%)	Gaps:	215/807 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRKHTRADKLKKRSNKYVL--------------- 58
            |:|:||..:|.:||....|||::||.|.::||:|.....:|:....:.|:
Frog     6 LTDEELFSELKRSGMMPGPVTDSTRPVYLKKLKKLREEQRLRHGKVRVVMNNNTVAAPSESEGIL 70

  Fly    59 ----------YSKE---------------------------------------QQESPP------ 68
                      ||::                                       |.|..|
Frog    71 KSGGDVTHKRYSRQSLPRESGKQSPILGFSSDESDADAGLGAHGSRRGRGNTPQSERKPVQQRGT 135

  Fly    69 ---------FPQYHQYHAPQPPQNYANGLDNNNDLDQ-----------------TGGSSAYNRSL 107
                     .|.:.:...||     .:..|:::|.|:                 .|...:|.|..
Frog   136 ADGDTDRRKVPGWWEMRRPQ-----GDSEDDDDDDDEEEEEEAAMEEASKCRTMNGSRHSYYRDY 195

  Fly   108 DESDSSPLQLSASKMYAPPPVVASNYDGDCSPHSLGLNGKYLQPCSMPYAIDTSNNY---GKPSG 169
            .::|.     ...|...|..............|.:..|.....|.......|.|:.:   .:.|.
Frog   196 SDTDE-----ELGKDEQPSRRNRRGSSKQARDHCMDRNDLPSWPGWSREVADVSHRHRGAARKSH 255

  Fly   170 KAKLSDGGVVNRLLSFRDTTIQRKFN-------YPTG------------------------QASR 203
            .|..|||  ...|....:..::..:|       :|:.                        |.|:
Frog   256 TAADSDG--AGNLKRKSNNHLESSYNKDPPRVYFPSNSLPPRMPQSNHTAASNHNYSHYQYQGSK 318

  Fly   204 IPLRKERLTRFALSDLKSFIRNP-----DIRPYVIPRVLISLFLIFLTIITVLYV--------GK 255
            ..|.|......||  |:.|.|..     ....:.:...|::...:|..::.:.|:        |:
Frog   319 RQLNKVSEPEEAL--LQQFKREEVSTAGGFSAHYLSMFLLTAACLFFLLLGLTYLRMRGTSLTGE 381

  Fly   256 RFEQSPIDKAALKYTLCNPNDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKDANL 320
            ...:||.|....:.|:...|.:|.:.||::....|.:.|..|.     |:::.:....:.|....
Frog   382 ENLRSPEDLNVDQSTIVLMNTLQKLHEKLSKTAGDYICGDTDR-----RNVSVQEASQYLKTLGK 441

  Fly   321 SPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITENPQWSIQVVDSTKHLGQTSHFELSEPNL 385
            ....|....|..::.         ||.........:.:| .||..:.|.|:|      |.:.|.:
Frog   442 EYEDEFNNTVAWILQ---------HSATRDVGIKCSSDP-GSILNITSVKYL------ESTLPRM 490

  Fly   386 PLKCIVLKKVTRFFTVI--GALLLIVAGFLIVYVAVVIYR-VKQKEALLAVDQFQKDIINELIYL 447
            ...|.:.:.|   .||.  .::.||..|.|...:..:.|| .|::|   ...|....::..:..|
Frog   491 SFMCRIRRAV---ITVAHRSSIFLIGVGVLFGVLRYMKYRWAKEEE---ETKQMYDMVVKIIDVL 549

  Fly   448 SSQSES--------PEVVINQLQEKFLPAKKRSKLLSSWNKALKQLEKNDSRVLFGMVNRDGKAM 504
            .|.:|:        |...|..:::..:..:.|.|:...|::|::.|:.|:|||........|...
Frog   550 KSHNEACQENKDLEPYTPIPHVRDSLILPQDRKKMKKVWDRAVEFLDANESRVRTETQKIGGADF 614

  Fly   505 RTIAW---NRNVDKKDVGLVKKWQSPAF--DNSNKIANPPTPCLKIRHMFDS-SEV-DQANLKQS 562
            :...|   :...||..|...|.||..||  |..|...|..|||||||:|||. .|: |..:|  :
Frog   615 QVWKWIQPSSTCDKISVMPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDHWDL--A 677

  Fly   563 IVESIIEKVGTRCKICDVQLDVQS--CCVYIRCASEEDAGTIHKEINGWWFDKRLISIKFLRLER 625
            |.|:|:||......|..:.:|..|  .|||::|.|.|.||...|.::|.|||.:|:::|:|||:|
Frog   678 IQEAILEKCSDNEGIVHIAVDKNSREGCVYVKCLSPEFAGKAFKALHGSWFDGKLVTVKYLRLDR 742

  Fly   626 YLSRFPKPSAEPLYFHTN---EAANTH 649
            |..|||:.      |..|   :.:|||
Frog   743 YHHRFPQA------FTCNTPLKPSNTH 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_001286812.1	LEM	4..47	CDD:128813	16/37 (43%)
		MSC	<381..509	CDD:286487	29/138 (21%)
		RRM_Man1	542..631	CDD:240732	40/92 (43%)
lemd3	XP_012813817.2	LEM_Man1	2..45	CDD:240589	16/38 (42%)
		MSC	<404..620	CDD:401378	48/242 (20%)
		RRM_Man1	657..748	CDD:409728	40/92 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4431
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D593495at33208
OrthoFinder	1	1.000	-	-		FOG0004711
OrthoInspector	1	1.000	-	-		oto102608
Panther	1	1.100	-	-	LDO	PTHR13428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2606
SonicParanoid	1	1.000	-	-		X5852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.100