Protein Alignment MAN1 and lemd3

DIOPT Version :10

• Sequence 1: NP_611873.1
• Gene: MAN1 / 37838
• FlyBaseID: FBgn0034962
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: XP_012813817.2
• Gene: lemd3 / 100038042
• XenbaseID: XB-GENE-486033
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 175/807 - (21%)
• Similarity: 291/807 - (36%)
• Gaps: 215/807 - (26%)

  Fly     9 LSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRKHTRADKLKKRSNKYVL--------------- 58
            |:|:||..:|.:||....|||::||.|.::||:|.....:|:....:.|:
 Frog     6 LTDEELFSELKRSGMMPGPVTDSTRPVYLKKLKKLREEQRLRHGKVRVVMNNNTVAAPSESEGIL 70

  Fly    59 ----------YSKE---------------------------------------QQESPP------ 68
                      ||::                                       |.|..|
 Frog    71 KSGGDVTHKRYSRQSLPRESGKQSPILGFSSDESDADAGLGAHGSRRGRGNTPQSERKPVQQRGT 135

  Fly    69 ---------FPQYHQYHAPQPPQNYANGLDNNNDLDQ-----------------TGGSSAYNRSL 107
                     .|.:.:...||     .:..|:::|.|:                 .|...:|.|..
 Frog   136 ADGDTDRRKVPGWWEMRRPQ-----GDSEDDDDDDDEEEEEEAAMEEASKCRTMNGSRHSYYRDY 195

  Fly   108 DESDSSPLQLSASKMYAPPPVVASNYDGDCSPHSLGLNGKYLQPCSMPYAIDTSNNY---GKPSG 169
            .::|.     ...|...|..............|.:..|.....|.......|.|:.:   .:.|.
 Frog   196 SDTDE-----ELGKDEQPSRRNRRGSSKQARDHCMDRNDLPSWPGWSREVADVSHRHRGAARKSH 255

  Fly   170 KAKLSDGGVVNRLLSFRDTTIQRKFN-------YPTG------------------------QASR 203
            .|..|||  ...|....:..::..:|       :|:.                        |.|:
 Frog   256 TAADSDG--AGNLKRKSNNHLESSYNKDPPRVYFPSNSLPPRMPQSNHTAASNHNYSHYQYQGSK 318

  Fly   204 IPLRKERLTRFALSDLKSFIRNP-----DIRPYVIPRVLISLFLIFLTIITVLYV--------GK 255
            ..|.|......||  |:.|.|..     ....:.:...|::...:|..::.:.|:        |:
 Frog   319 RQLNKVSEPEEAL--LQQFKREEVSTAGGFSAHYLSMFLLTAACLFFLLLGLTYLRMRGTSLTGE 381

  Fly   256 RFEQSPIDKAALKYTLCNPNDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKDANL 320
            ...:||.|....:.|:...|.:|.:.||::....|.:.|..|.     |:::.:....:.|....
 Frog   382 ENLRSPEDLNVDQSTIVLMNTLQKLHEKLSKTAGDYICGDTDR-----RNVSVQEASQYLKTLGK 441

  Fly   321 SPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITENPQWSIQVVDSTKHLGQTSHFELSEPNL 385
            ....|....|..::.         ||.........:.:| .||..:.|.|:|      |.:.|.:
 Frog   442 EYEDEFNNTVAWILQ---------HSATRDVGIKCSSDP-GSILNITSVKYL------ESTLPRM 490

  Fly   386 PLKCIVLKKVTRFFTVI--GALLLIVAGFLIVYVAVVIYR-VKQKEALLAVDQFQKDIINELIYL 447
            ...|.:.:.|   .||.  .::.||..|.|...:..:.|| .|::|   ...|....::..:..|
 Frog   491 SFMCRIRRAV---ITVAHRSSIFLIGVGVLFGVLRYMKYRWAKEEE---ETKQMYDMVVKIIDVL 549

  Fly   448 SSQSES--------PEVVINQLQEKFLPAKKRSKLLSSWNKALKQLEKNDSRVLFGMVNRDGKAM 504
            .|.:|:        |...|..:::..:..:.|.|:...|::|::.|:.|:|||........|...
 Frog   550 KSHNEACQENKDLEPYTPIPHVRDSLILPQDRKKMKKVWDRAVEFLDANESRVRTETQKIGGADF 614

  Fly   505 RTIAW---NRNVDKKDVGLVKKWQSPAF--DNSNKIANPPTPCLKIRHMFDS-SEV-DQANLKQS 562
            :...|   :...||..|...|.||..||  |..|...|..|||||||:|||. .|: |..:|  :
 Frog   615 QVWKWIQPSSTCDKISVMPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDHWDL--A 677

  Fly   563 IVESIIEKVGTRCKICDVQLDVQS--CCVYIRCASEEDAGTIHKEINGWWFDKRLISIKFLRLER 625
            |.|:|:||......|..:.:|..|  .|||::|.|.|.||...|.::|.|||.:|:::|:|||:|
 Frog   678 IQEAILEKCSDNEGIVHIAVDKNSREGCVYVKCLSPEFAGKAFKALHGSWFDGKLVTVKYLRLDR 742

  Fly   626 YLSRFPKPSAEPLYFHTN---EAANTH 649
            |..|||:.      |..|   :.:|||
 Frog   743 YHHRFPQA------FTCNTPLKPSNTH 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN1	NP_611873.1	LEM	4..47	CDD:128813	16/37 (43%)
		RRM_Man1	542..631	CDD:409728	40/92 (43%)
lemd3	XP_012813817.2	LEM_Man1	2..45	CDD:240589	16/38 (42%)
		MSC	<404..620	CDD:430586	48/242 (20%)
		RRM_Man1	657..748	CDD:409728	40/92 (43%)