DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and ak8

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001018480.1	Gene:	ak8 / 553671	ZFINID:	ZDB-GENE-050522-275	Length:	486	Species:	Danio rerio

Alignment Length:	220	Identity:	60/220 - (27%)
Similarity:	112/220 - (50%)	Gaps:	14/220 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RYEPENIGINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLGAELKKVMDAGK 75
            |:.|.......:|.||||:|:..||.|:.:|:.:.::..|::|:|..:..|.:|..:|..:::.:
Zfish   261 RHSPSPYTPRILLFGPPGAGRNLQAKLIAQKYGIINICCGELLKAVSADESHMGELIKPYLESEQ 325

  Fly    76 LVSDDLVVDMIDSNLDKPEC-KNGFLLDGFPRTVVQAEKLDTLLDKRKTNLDAVIEFAIDDSLLV 139
            .|...:|:.::...|.:.:| ..|::|.||||.|.:||    ||.|.....:.|....|.|.:.:
Zfish   326 QVPSSIVLRVLTERLSRMDCTARGWVLHGFPRDVEEAE----LLHKSNFTPNRVFFLEITDDIAI 386

  Fly   140 RRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEA-LKKRLEAYHKQTKPLVDY 203
            .|:..|.:...:|..||..:.||..|..     :..:|.:..::|| |..||:.|..||..|..:
Zfish   387 ERLALRAVDPVTGEWYHSVYKPPPGPEV-----QARLRFNPQHSEAQLLMRLKEYWSQTVRLQAF 446

  Fly   204 YGLRGLHFKVDAAKKSSDVFSTIDS 228
            |. :.::  ::|.:....||.:::|
Zfish   447 YP-QAVY--INADQDPHTVFESLES 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	58/211 (27%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	55/203 (27%)
ak8	NP_001018480.1	Adenylate kinase 1. /evidence=ECO:0000250\|UniProtKB:Q96MA6	58..258
		adk	59..257	CDD:273569
		ADK	59..245	CDD:238713
		NMP 1. /evidence=ECO:0000250\|UniProtKB:P69441	87..112
		LID 1. /evidence=ECO:0000250\|UniProtKB:P69441	176..205
		Adenylate kinase 2. /evidence=ECO:0000250\|UniProtKB:Q96MA6	269..471		58/212 (27%)
		adk	270..470	CDD:273569	58/211 (27%)
		ADK	270..462	CDD:238713	55/203 (27%)
		NMP 2. /evidence=ECO:0000250\|UniProtKB:P69441	298..327		6/28 (21%)
		LID 2. /evidence=ECO:0000250\|UniProtKB:P69441	391..424		8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900