DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and ak2

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_997761.1	Gene:	ak2 / 321793	ZFINID:	ZDB-GENE-030131-512	Length:	241	Species:	Danio rerio

Alignment Length:	235	Identity:	154/235 - (65%)
Similarity:	185/235 - (78%)	Gaps:	11/235 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPNAAVPVERYEPENI-----GINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSG 60
            |||:.      .|.:.:     ||.||||||||:|||||||.|.||:|||||:|||||||.::||
Zfish     1 MAPST------QEDDTVSGIRKGIRAILLGPPGAGKGTQAPKLAEKYCVCHLATGDMLRAMVASG 59

  Fly    61 SKLGAELKKVMDAGKLVSDDLVVDMIDSNLDKPECKNGFLLDGFPRTVVQAEKLDTLLDKRKTNL 125
            |:||..||:.|||||||||::||::||:|||.|.||||||||||||||.|||.||.|::||...|
Zfish    60 SELGQRLKETMDAGKLVSDEMVVELIDNNLDTPSCKNGFLLDGFPRTVKQAEMLDDLMEKRSEKL 124

  Fly   126 DAVIEFAIDDSLLVRRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEALKKRL 190
            |:||||::|||||||||.||||||.|||||||||.|||:.|.|||||||||||||||...|:.||
Zfish   125 DSVIEFSVDDSLLVRRICGRLIHQPSGRSYHEEFHPPKEHMKDDVTGEPLIRRSDDNETTLRSRL 189

  Fly   191 EAYHKQTKPLVDYYGLRGLHFKVDAAKKSSDVFSTIDSIF 230
            |:||:||.|||.||..||||..:||::.:..||::|.:.|
Zfish   190 ESYHRQTSPLVQYYSARGLHTAIDASQSTDLVFASILAAF 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	148/211 (70%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	144/201 (72%)
ak2	NP_997761.1	adk	19..231	CDD:234711	148/211 (70%)
		ADK	19..221	CDD:238713	144/201 (72%)
		NMP. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168	47..76		19/28 (68%)
		LID. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168	143..180		31/36 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..180		23/27 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592484
Domainoid	1	1.000	286	1.000	Domainoid score	I1570
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1227
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2569
OMA	1	1.010	-	-		QHG53706
OrthoDB	1	1.010	-	-		D1004067at2759
OrthoFinder	1	1.000	-	-		FOG0003181
OrthoInspector	1	1.000	-	-		oto39884
orthoMCL	1	0.900	-	-		OOG6_100712
Panther	1	1.100	-	-	LDO	PTHR23359
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R630
SonicParanoid	1	1.000	-	-		X2141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.890