DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and AK2

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001616.1	Gene:	AK2 / 204	HGNCID:	362	Length:	239	Species:	Homo sapiens

Alignment Length:	233	Identity:	155/233 - (66%)
Similarity:	188/233 - (80%)	Gaps:	5/233 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPNAAVPVERYEPE-NIGINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLG 64
            |||  :||..  ||| ..||.|:||||||:|||||||.|.|.||||||:|||||||.::|||:||
Human     1 MAP--SVPAA--EPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELG 61

  Fly    65 AELKKVMDAGKLVSDDLVVDMIDSNLDKPECKNGFLLDGFPRTVVQAEKLDTLLDKRKTNLDAVI 129
            .:||..|||||||||::||::|:.||:.|.||||||||||||||.|||.||.|::|||..||:||
Human    62 KKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVI 126

  Fly   130 EFAIDDSLLVRRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEALKKRLEAYH 194
            ||:|.||||:|||||||||..|||||||||.|||:||.||:||||||||||||.:|||.||:|||
Human   127 EFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYH 191

  Fly   195 KQTKPLVDYYGLRGLHFKVDAAKKSSDVFSTIDSIFQR 232
            .||.||::||..||:|..:||::....||::|.:.|.:
Human   192 TQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSK 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	145/213 (68%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	141/201 (70%)
AK2	NP_001616.1	ADK	20..204	CDD:395329	135/183 (74%)
		NMP. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168, ECO:0000269\|Ref.17	45..74		19/28 (68%)
		LID. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168, ECO:0000269\|Ref.17	141..178		30/36 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..169		14/18 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156831
Domainoid	1	1.000	284	1.000	Domainoid score	I1641
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1227
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2615
Isobase	1	0.950	-	0	Normalized mean entropy	S240
OMA	1	1.010	-	-		QHG53706
OrthoDB	1	1.010	-	-		D1004067at2759
OrthoFinder	1	1.000	-	-		FOG0003181
OrthoInspector	1	1.000	-	-		oto88921
orthoMCL	1	0.900	-	-		OOG6_100712
Panther	1	1.100	-	-	LDO	PTHR23359
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R630
SonicParanoid	1	1.000	-	-		X2141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.980