DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and AK8

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	XP_005272226.1	Gene:	AK8 / 158067	HGNCID:	26526	Length:	491	Species:	Homo sapiens

Alignment Length:	239	Identity:	62/239 - (25%)
Similarity:	110/239 - (46%)	Gaps:	28/239 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YEPENIGINA------ILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLGAELKKV 70
            |...|...||      :||||.||||..||.||.:|:.:.::..|.:|:..::..:..|..::..
Human   268 YVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPF 332

  Fly    71 MDAGKLVSDDLVVDMIDSNLDKPEC-KNGFLLDGFPRTVVQAEKLDTLLDKRKTNLDAVIEFAID 134
            .:....|.|.|::.::...||:.:| :.|::|.|.||.:.||.    ||::...|.:.|....:.
Human   333 FEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAH----LLNRLGYNPNRVFFLNVP 393

  Fly   135 DSLLVRRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEALKKRLEAYHKQTKP 199
            ...::.|:|.|.|...:|..||..:.||.   |.::... |::...|..|.:|.:::.:::.:..
Human   394 FDSIMERLTLRRIDPVTGERYHLMYKPPP---TMEIQAR-LLQNPKDAEEQVKLKMDLFYRNSAD 454

  Fly   200 LVDYYGLRGLHFKVDAAKKSSD-----VFSTIDSIFQRKRPAQI 238
            |...||        .|...:.|     ||..|:|......|.:|
Human   455 LEQLYG--------SAITLNGDQDPYTVFEYIESGIINPLPKKI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	58/224 (26%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	54/213 (25%)
AK8	XP_005272226.1	adk	71..270	CDD:273569	1/1 (100%)
		ADK	71..261	CDD:238713
		adk	282..480	CDD:273569	55/213 (26%)
		ADK	282..474	CDD:238713	52/207 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900