DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and AK7

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	XP_006720084.1	Gene:	AK7 / 122481	HGNCID:	20091	Length:	730	Species:	Homo sapiens

Alignment Length:	187	Identity:	46/187 - (24%)
Similarity:	74/187 - (39%)	Gaps:	50/187 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 INAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLGA------------------ 65
            |...:||||..||.:.|..|...:.:.|:...|::...|   :||.|
Human   368 IKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAI---AKLEAIVAPNDVGEGEEEVEEEE 429

  Fly    66 ELKKVMDAGKL--------------VSDDLVVDMIDSNLDKPECKN-GFLLDGFPRTVVQAEKLD 115
            |.:.|.||.:|              :.|..::..:...|....|:| |::|||||:|..||:.|.
Human   430 EEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLF 494

  Fly   116 TLLDKRKTN--------LDAVI--EF--AID--DSLLVRRITGRLIHQASGRSYHEE 158
            ...|:.:.:        .|.:|  ||  |:|  |..|..|:........:|..|.::
Human   495 NQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	45/186 (24%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	45/186 (24%)
AK7	XP_006720084.1	WcaG	<147..310	CDD:223528
		NADB_Rossmann	<149..307	CDD:304358
		ADK	369..>548	CDD:238713	44/181 (24%)
		Dpy-30	679..>711	CDD:253069
		GVQW	713..>730	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900