DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adk2 and Ak2

DIOPT Version :9

Sequence 1:	NP_523836.2	Gene:	Adk2 / 37834	FlyBaseID:	FBgn0283494	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001029138.1	Gene:	Ak2 / 11637	MGIID:	87978	Length:	239	Species:	Mus musculus

Alignment Length:	233	Identity:	157/233 - (67%)
Similarity:	187/233 - (80%)	Gaps:	5/233 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPNAAVPVERYEPE-NIGINAILLGPPGSGKGTQAPLLKEKFCVCHLSTGDMLRAEISSGSKLG 64
            ||||    |...||| ..||.|:||||||:|||||||.|.|.||||||:|||||||.::|||:||
Mouse     1 MAPN----VLASEPEIPKGIRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELG 61

  Fly    65 AELKKVMDAGKLVSDDLVVDMIDSNLDKPECKNGFLLDGFPRTVVQAEKLDTLLDKRKTNLDAVI 129
            .:||..|||||||||::||::|:.||:.|.||||||||||||||.|||.||.|::|||..||:||
Mouse    62 KKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVI 126

  Fly   130 EFAIDDSLLVRRITGRLIHQASGRSYHEEFAPPKKPMTDDVTGEPLIRRSDDNAEALKKRLEAYH 194
            ||:|.||||:|||||||||..|||||||||.|||:||.||:||||||||||||.:|||.||||||
Mouse   127 EFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKTRLEAYH 191

  Fly   195 KQTKPLVDYYGLRGLHFKVDAAKKSSDVFSTIDSIFQR 232
            .||.|||:||..||:|..:||::....||::|.:.|.:
Mouse   192 TQTTPLVEYYRKRGIHCAIDASQTPDIVFASILAAFSK 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adk2	NP_523836.2	adk	20..233	CDD:234711	147/213 (69%)
Adk2	NP_523836.2	ADK	20..222	CDD:238713	143/201 (71%)
Ak2	NP_001029138.1	ADK	17..219	CDD:238713	143/201 (71%)
		ADK	20..204	CDD:278818	137/183 (75%)
		NMP. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168	45..74		19/28 (68%)
		LID. /evidence=ECO:0000255\|HAMAP-Rule:MF_03168	141..178		30/36 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847243
Domainoid	1	1.000	288	1.000	Domainoid score	I1567
eggNOG	1	0.900	-	-		E1_COG0563
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1227
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2560
Isobase	1	0.950	-	0	Normalized mean entropy	S240
OMA	1	1.010	-	-		QHG53706
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003181
OrthoInspector	1	1.000	-	-		oto92488
orthoMCL	1	0.900	-	-		OOG6_100712
Panther	1	1.100	-	-	LDO	PTHR23359
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R630
SonicParanoid	1	1.000	-	-		X2141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.830