DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xxylt and LARGE1

DIOPT Version :9

Sequence 1:	NP_611871.2	Gene:	Xxylt / 37833	FlyBaseID:	FBgn0034959	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001349878.1	Gene:	LARGE1 / 9215	HGNCID:	6511	Length:	756	Species:	Homo sapiens

Alignment Length:	438	Identity:	103/438 - (23%)
Similarity:	168/438 - (38%)	Gaps:	109/438 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CRWQKK-LVLLLIFICV-CVLIVFANTHLLVRGNILSAFLSSRLNKHSHA-----------EKQE 114
            ||.::| |...|..:|: .:..::..:.....|..:|.   |.|...:|:           |..|
Human     5 CRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSL---SPLESQAHSPRYTASSQRERESLE 66

  Fly   115 ARYPDIPATTPSVPPVL------RPTHYLLNYSST-QLEL----SSHLN-----GLSSD------ 157
            .|..::.....::...|      .|:|...|:|.| .:|.    |.:|.     |.||:
Human    67 VRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPV 131

  Fly   158 ----YNIFVIYTRENYHLNLKFDLFAHSLLKHTSAQLHLHVITDSESQPSVLEILQRQIRRFRRT 218
                ..|.|......|:.:........|:|.|....||.|:|.||.::                .
Human   132 VEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAE----------------Q 180

  Fly   219 VIYTIYDVKVCSSIIQDI--AAKLSPYFSSTPNSYYSDSLFFLSLGLHRIADRSLNRAILLDCDI 281
            ::.|::...:..::..|.  |.:|....|..||.:||.....:.|.|.:....:|.|.|:||.||
Human   181 ILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDI 245

  Fly   282 VFRSDVRLLFNEFDNFLPHQLYGLAPELTPVYRHILYRYRVRYPKTSFGNPYYPINNEGGNQHSR 346
            .|.:|:..|:..|..|...|:.||....:..|               .||.:            :
Human   246 TFATDIAELWAVFHKFKGQQVLGLVENQSDWY---------------LGNLW------------K 283

  Fly   347 VHHGYP----GLNSGVVLLLLNRIRNSKSYLEKLTHSEVHTLVAKYSFKG----HLGDQDFFTLL 403
            .|..:|    |.|:||:||||:::|       |:...::..|.|:....|    .|.|||.|..:
Human   284 NHRPWPALGRGYNTGVILLLLDKLR-------KMKWEQMWRLTAERELMGMLSTSLADQDIFNAV 341

  Fly   404 GYEYPNLIYRLDCIWNRQLCTWWKDHGYSQIFDAYFRCEGNIKMYHGN 451
            ..:.|.|:|:|.|.||.||    .||..|   :..:|...::|:.|.|
Human   342 IKQNPFLVYQLPCFWNVQL----SDHTRS---EQCYRDVSDLKVIHWN 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xxylt	NP_611871.2	Glyco_tranf_GTA_type	172..>422	CDD:299700	65/259 (25%)
LARGE1	NP_001349878.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..69		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109		7/27 (26%)
		GT8_LARGE_C	138..417	CDD:133053	77/302 (25%)
		Xylosyltransferase activity. /evidence=ECO:0000305\|PubMed:22223806	138..413		77/302 (25%)
		Glucuronyltransferase activity. /evidence=ECO:0000305\|PubMed:22223806	414..756
		Glyco_transf_49	473..742	CDD:404735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8703
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810