DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xxylt and Large1

DIOPT Version :9

Sequence 1:	NP_611871.2	Gene:	Xxylt / 37833	FlyBaseID:	FBgn0034959	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001304320.1	Gene:	Large1 / 16795	MGIID:	1342270	Length:	756	Species:	Mus musculus

Alignment Length:	440	Identity:	105/440 - (23%)
Similarity:	169/440 - (38%)	Gaps:	113/440 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CRWQKK-LVLLLIFICVCV---LIVFANTHLLVRGNILSAFLSSRLNKHSHA-----------EK 112
            ||.::| |...|..:|:..   :.:||.:  ...|..:|.   |.|...:|:           |.
Mouse     5 CRGRRKFLAASLTLLCIPAITWIYLFAGS--FEDGKPVSL---SPLESQAHSPRYTASSQRERES 64

  Fly   113 QEARYPDIPATTPSVPPVL------RPTHYLLNYSST-QLEL----SSHLN-----GLSSD---- 157
            .|.|..::.....::...|      .|.|:..|:|.| .:|.    |.:|.     |.||:
Mouse    65 LEVRVREVEEENRALRRQLSLAQGQSPAHHRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQ 129

  Fly   158 ------YNIFVIYTRENYHLNLKFDLFAHSLLKHTSAQLHLHVITDSESQPSVLEILQRQIRRFR 216
                  ..|.|......|:.:........|:|.|....||.|:|.||.::
Mouse   130 PAVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAE--------------- 179

  Fly   217 RTVIYTIYDVKVCSSIIQDI--AAKLSPYFSSTPNSYYSDSLFFLSLGLHRIADRSLNRAILLDC 279
             .::.|::...:..::..|.  |.:|....|..||.:||.....:.|.|.:....:|.|.|:||.
Mouse   180 -QILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDT 243

  Fly   280 DIVFRSDVRLLFNEFDNFLPHQLYGLAPELTPVYRHILYRYRVRYPKTSFGNPYYPINNEGGNQH 344
            ||.|.:|:..|:..|..|...|:.||....:..|               .||.:
Mouse   244 DITFATDIAELWAVFHKFKGQQVLGLVENQSDWY---------------LGNLW----------- 282

  Fly   345 SRVHHGYP----GLNSGVVLLLLNRIRNSKSYLEKLTHSEVHTLVAKYSFKG----HLGDQDFFT 401
             :.|..:|    |.|:||:||||:::|       |:...::..|.|:....|    .|.|||.|.
Mouse   283 -KNHRPWPALGRGYNTGVILLLLDKLR-------KMKWEQMWRLTAERELMGMLSTSLADQDIFN 339

  Fly   402 LLGYEYPNLIYRLDCIWNRQLCTWWKDHGYSQIFDAYFRCEGNIKMYHGN 451
            .:..:.|.|:|:|.|.||.||    .||..|   :..:|...::|:.|.|
Mouse   340 AVIKQNPFLVYQLPCFWNVQL----SDHTRS---EQCYRDVSDLKVIHWN 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xxylt	NP_611871.2	Glyco_tranf_GTA_type	172..>422	CDD:299700	65/259 (25%)
Large1	NP_001304320.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..64		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..108		7/25 (28%)
		GT8_LARGE_C	138..417	CDD:133053	77/302 (25%)
		Xylosyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	138..413		77/302 (25%)
		Glucuronyltransferase activity. /evidence=ECO:0000250\|UniProtKB:O95461	414..756
		Glyco_transf_49	473..742	CDD:372794
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910