DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xxylt and XXYLT1

DIOPT Version :9

Sequence 1:	NP_611871.2	Gene:	Xxylt / 37833	FlyBaseID:	FBgn0034959	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_689744.3	Gene:	XXYLT1 / 152002	HGNCID:	26639	Length:	393	Species:	Homo sapiens

Alignment Length:	416	Identity:	153/416 - (36%)
Similarity:	220/416 - (52%)	Gaps:	77/416 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VLLLIFICVCVLIVFANTHLLVRGNILSAFLSSRLNKHSHAEK--QEARYPDIPATTPSVPPVLR 132
            :||...:.||...                :|.|.....|.|.|  :|||     |..|:.|
Human    27 LLLAAALAVCAFY----------------YLGSGRETFSSATKRLKEAR-----AGAPAAP---- 66

  Fly   133 PTHYLLNYSSTQLEL------------SSHLNGLSS---DYNIFVIYTR--ENYHLNLKFDLFAH 180
                    |...|||            :..|.|..:   ||::.:::|:  .|..|..|..:...
Human    67 --------SPPALELARGSVAPAPGAKAKSLEGGGAGPVDYHLLMMFTKAEHNAALQAKARVALR 123

  Fly   181 SLLKHTSAQLH----LHVITDSESQPSVLEILQRQI----RRFRRTVIYTIYDVKVCSSIIQDIA 237
            |||:....:.|    ||.::: |:...|.:.|.|::    ..|:..||:  :||.|.:..:..|.
Human   124 SLLRLAKFEAHEVLNLHFVSE-EASREVAKGLLRELLPPAAGFKCKVIF--HDVAVLTDKLFPIV 185

  Fly   238 AKLSPYFSSTPNSYYSDSLFFLSLGLHRIADRSLNRAILLDCDIVFRSDVRLLFNEFDNFLPHQL 302
            ..:..:||:...:|||||:||||:.:|:|..:.:.:.|.||.|:.|::::|.||.|||:|||..:
Human   186 EAMQKHFSAGLGTYYSDSIFFLSVAMHQIMPKEILQIIQLDLDLKFKTNIRELFEEFDSFLPGAI 250

  Fly   303 YGLAPELTPVYRHILYRYRVRYPKTSFGNPYYPINNEGGNQHSRVHHGYPGLNSGVVLLLLNRIR 367
            .|:|.|:.|||||..:::|...|:|..|.|              ...|.||.||||:||.|..:|
Human   251 IGIAREMQPVYRHTFWQFRHENPQTRVGGP--------------PPEGLPGFNSGVMLLNLEAMR 301

  Fly   368 NSKSYLEKLTHSEVHTLVAKYSFKGHLGDQDFFTLLGYEYPNLIYRLDCIWNRQLCTWWKDHGYS 432
            .|..|...|..::|..|..||.|:||||||||||::|.|:|.|.:.|||.|||||||||:|||||
Human   302 QSPLYSRLLEPAQVQQLADKYHFRGHLGDQDFFTMIGMEHPKLFHVLDCTWNRQLCTWWRDHGYS 366

  Fly   433 QIFDAYFRCEGNIKMYHGNCNTRIPE 458
            .:|:|||||||::|:|||||||.|||
Human   367 DVFEAYFRCEGHVKIYHGNCNTPIPE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xxylt	NP_611871.2	Glyco_tranf_GTA_type	172..>422	CDD:299700	97/257 (38%)
XXYLT1	NP_689744.3	UDP-alpha-D-xylose binding. /evidence=ECO:0000250\|UniProtKB:Q3U4G3	104..106		0/1 (0%)
		Glyco_tranf_GTA_type	120..383	CDD:299700	116/279 (42%)
		RfaJ	162..>353	CDD:224359	83/206 (40%)
		Interaction with target proteins. /evidence=ECO:0000250\|UniProtKB:Q3U4G3	263..266		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159410
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H17610
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49966
OrthoDB	1	1.010	-	-		D358215at33208
OrthoFinder	1	1.000	-	-		FOG0007489
OrthoInspector	1	1.000	-	-		oto90779
orthoMCL	1	0.900	-	-		OOG6_108545
Panther	1	1.100	-	-	LDO	PTHR46612
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5793
SonicParanoid	1	1.000	-	-		X5614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800