DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rsph4a and Rsph4a

DIOPT Version :9

Sequence 1:	NP_611869.1	Gene:	Rsph4a / 37831	FlyBaseID:	FBgn0034957	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001156429.1	Gene:	Rsph4a / 212892	MGIID:	3027894	Length:	716	Species:	Mus musculus

Alignment Length:	765	Identity:	232/765 - (30%)
Similarity:	341/765 - (44%)	Gaps:	199/765 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSSHFAPP---------------PVCAPRRKKPEKPAAEEASP-------------ECSNVTSSS 51
            |||...||               ||.|...:|.....|:..:|             ..|:.||.:
Mouse    80 SSSPPPPPLQFHSTPLNTETTQDPVAASPTEKTANGIADTGTPYSDPWESSSAAKQSTSHYTSHA 144

  Fly    52 SSSTTTISIGAFDSQCNLHNA-RN----------------------PEAPNIG----------YE 83
            ..||...|.......|.|.:| ||                      |:.|.:|          ..
Mouse   145 EESTFPQSQTPQPDLCGLRDASRNKSKHKGLRFDLLQEEGSDSNCDPDQPEVGASEAAQSMLEVA 209

  Fly    84 LNVAKSILQKYSTLSGDNLFDHLSDIIKRVIDERPPNVIDFFEEFSRNVREQKFHLP-------- 140
            :..||:.|...|:.||.||:||||.::.:::||||.:.:|..|..|::|:...|:..
Mouse   210 IQNAKAYLLSTSSKSGLNLYDHLSKVLTKILDERPADAVDIIENISQDVKMAHFNKKLDTLHNEY 274

  Fly   141 ERFPPSGVFDEVRSFRVAKKILQSMKLPYVVEGEDLMGEDLSVEDLRTNEDMRIVIDDSMRYFVT 205
            |..|             |.:|.::.|..: ::|. |.|.|..:|:......:..|::.:
Mouse   275 EMLP-------------AYEIAETQKALF-LQGH-LEGADSELEEEMAESSLPNVMESA------ 318

  Fly   206 FNERVQQLQFYWTQCGFSISNDDIFQLASAMNRL-QTHPSIMQCRFWGCINGLKASYYIVEASLT 269
                     :|:.|.|..:..|:.:::..|:.:| .||| |.:|||||.|.||:.:|.:.|....
Mouse   319 ---------YYFEQAGVGLGTDETYRVFLALKQLTDTHP-IQRCRFWGKILGLEMNYIVAEVEFR 373

  Fly   270 REEIASRLVMMEEEMRQKQIPFPMRKDREDKPPPAHIGPELTPGIYGWEEFPPEELEKMKPKAAP 334
            ..|       .|||:.::.|    .::|::....|           |.||  .|||.|...||..
Mouse   374 DGE-------DEEEVEEEGI----AEERDNGGSEA-----------GEEE--EEELPKSLYKAPQ 414

  Fly   335 VPLVEEMELYDIPPEFIGKGCNRYSYFVVNSLFDDWIELPIVTPRQIVVSRQIKKFLTGDLEADV 399
            |          ||.|....|.|:|.|||.|.....|:.||.|||.|||.:|:||||.||.|:|.|
Mouse   415 V----------IPKEESRTGANKYVYFVCNVPGRPWVRLPSVTPAQIVTARKIKKFFTGRLDAAV 469

  Fly   400 ISYPCFPGKEKHYLRTLIGRITAGTYIAPVGYYRRMTKKEQRMFDGEEEEEGEEEEEEEEEEEFN 464
            ||||.|||.|.:|||..|.||:|||:::|:|:|:         |.   ||||||||.|...:.:.
Mouse   470 ISYPPFPGNESNYLRAQIARISAGTHVSPLGFYQ---------FG---EEEGEEEEVEGGRDSYE 522

  Fly   465 EGEE-EQIEDNDVMLLKNEKYEAEPLGSLATPVAWVHVRSNILNQQGRVVWYDEEKARKEREKAL 528
            |..: |.|:..|::         |.|.:      |||....|| .|||..|::
Mouse   523 ENPDFEGIQVIDLV---------ESLSN------WVHHVQYIL-PQGRCNWFN------------ 559

  Fly   529 ALYLKMQMLGEMEEEVEEEEDEEEGEEEGEEEGMIEGFNQPELGPSILSSCANDMNPEVPVSWLA 593
                      .::::.:|||:|||.||:|||...||    .|:||.:|:..:.|:..:...||..
Mouse   560 ----------PIQKDEDEEEEEEEDEEKGEEPDYIE----QEVGPPLLTPISEDLGIQNIPSWTT 610

  Fly   594 RMTSKYTNQKERMLVMQSNVWPGAYTFIFEKTCESIYLGWGHKYYARNIPFKHLPMVQEEFPHNP 658
            :::|....| ..:.|::||:|||||.|...|..|:.|:||||||...|......|.|.:|:|..|
Mouse   611 QLSSNLIPQ-YAIAVLRSNLWPGAYAFSNGKKFENFYIGWGHKYCVENYTPPSPPPVYQEYPSGP 674

  Fly   659 EDFVEANDPTVEEEEAYKAWLLRKQQKAEYVAEDIEDYDDDEFADQYDDD 708
            | ..|.|||:||||:|::       ...|.||...|:.:..|..|:.|:|
Mouse   675 E-ITEMNDPSVEEEQAFR-------MTQEPVALSTEENEGTEDEDEDDED 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rsph4a	NP_611869.1	Radial_spoke	83..679	CDD:282555	199/605 (33%)
Rsph4a	NP_001156429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..167		31/147 (21%)
		Radial_spoke	209..691	CDD:282555	153/483 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..413		11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..586		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..716		20/47 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849819
Domainoid	1	1.000	263	1.000	Domainoid score	I1915
eggNOG	1	0.900	-	-		E1_28KDA
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3006
Isobase	1	0.950	-	0	Normalized mean entropy	S7891
OMA	1	1.010	-	-		QHG56376
OrthoDB	1	1.010	-	-		D166599at33208
OrthoFinder	1	1.000	-	-		FOG0005828
OrthoInspector	1	1.000	-	-		otm43242
orthoMCL	1	0.900	-	-		OOG6_102738
Panther	1	1.100	-	-	LDO	PTHR13159
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6491
SonicParanoid	1	1.000	-	-		X4222
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.750