Protein Alignment CG3860 and OSBPL2

DIOPT Version :10

• Sequence 1: NP_001286802.1
• Gene: CG3860 / 37825
• FlyBaseID: FBgn0034951
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_653081.1
• Gene: OSBPL2 / 9885
• HGNCID: 15761
• Length: 480
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 224/459 - (48%)
• Similarity: 290/459 - (63%)
• Gaps: 36/459 - (7%)

  Fly     3 EGDYAEHVERTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQL 67
            |....:|  ||.|||.|.||.:.|:|.|||.|:|.:|||||||:..|||||||||:.||||:..|
Human    54 ENGIQKH--RTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYL 116

  Fly    68 LTEAAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPP 130
            :..|:.|..|.:||:.||||||||:||.|||.||||||||||||||.:.|  :|.:.||||||||
Human   117 IHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPP 181

  Fly   131 VSAFHAE--SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGR 193
            :||||:|  :.||.|||:|.||:||||||||..|:||:|:|..|.||:|:|||..|||||:|:|:
Human   182 ISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGK 246

  Fly   194 LWIEQYGKMEITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSA 258
            |||||||.:||.||.|||...|.||..|...|.||:|||.::|.::..|:.:||||||.:.....
Human   247 LWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDP 311

  Fly   259 ESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKS 323
            .||..|.|| .|:.|               .|...||:.....:..||:.          |:|.:
Human   312 VSYESFKKQ-ERRGD---------------HLRKAKLDEDSGKADSDVAD----------DVPVA 350

  Fly   324 DSAYSLDIPDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLE 388
            .....: ||.|..||....||.|.::.|.||.|.:.||.:::.|:.  ||.|||.||||||..:|
Human   351 QETVQV-IPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEK--TLPPTDCRLRPDIRGME 412

  Fly   389 EGNLDGASKEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNT 453
            .||:|.||:||.|||||||..|::|....: :|..|||....||:|...||||:|.|::|.:.:.
Human   413 NGNMDLASQEKERLEEKQREARRERAKEEA-EWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDC 476

  Fly   454 DTIF 457
            ..|:
Human   477 PDIY 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..450	CDD:460126	213/427 (50%)
OSBPL2	NP_653081.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60		1/5 (20%)
		Oxysterol_BP	75..471	CDD:460126	212/425 (50%)