DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3860 and OSH2

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_010265.1	Gene:	OSH2 / 851543	SGDID:	S000002177	Length:	1283	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	159/460 - (34%)
Similarity:	230/460 - (50%)	Gaps:	63/460 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEGDYAEHVE--RTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYME 63
            :.||.|..:.:  |..|......|.::|:||:||:.:|||::::|:||..|||.|.|||:.|.:|
Yeast   870 LKEGSYLGYEDGIRKRLSMDKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEPTSLLQRVAEDLE 934

  Fly    64 YAQLLTEAAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVS 126
            |::||.:||..|....|..|||||..|:.||..:|:.||||||||||:|..:.|  ||...||||
Yeast   935 YSELLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQVS 999

  Fly   127 HHPPVSAFHAESKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEF-PKWNES---YSWTNVNCCVH 187
            ||||:||...||..:.|.|......||.|:|..|...|...::. |..||.   |:|...|..|.
Yeast  1000 HHPPISATWTESPRWDFWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVI 1064

  Fly   188 NIIVGRLWIEQYGKMEITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEF 252
            .|::|...::.:|::.:.||.||....|.||:.|..:...:.:.|.|.:..:..::.|.|.|.|.
Yeast  1065 GILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVYNKKKQKVWILGGHWNEA 1129

  Fly   253 IKCCSAESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQE 317
            |          |.|:..:     ||                           |:|.:........
Yeast  1130 I----------FAKKVVK-----DG---------------------------DLSLEKTRTAASA 1152

  Fly   318 GDIPKSDSAYSLDIPDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRP 382
            |:.|..|....|       :|....||   .|.:..|.||:.|||...::.|  .|.|||:||||
Yeast  1153 GNGPTDDGTKFL-------IWKANDRP---EEPFNLTPFAITLNAPQPHLLP--WLPPTDTRLRP 1205

  Fly   383 DILHLEEGNLDGASKEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWD 447
            |...:|:|..|.|..||.|:|||||..|::|:..|. ::.|:||...|:|.||...|.|:|.||.
Yeast  1206 DQRAMEDGRYDEAGDEKFRVEEKQRAARRKREENNL-EYHPQWFVRDTHPITKAKYWRYTGKYWV 1269

  Fly   448 RKYDN 452
            ::.|:
Yeast  1270 KRRDH 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	148/420 (35%)
OSH2	NP_010265.1	ANKYR	<47..194	CDD:223738
		ANK repeat	60..104	CDD:293786
		ANK repeat	106..137	CDD:293786
		Ank_5	191..247	CDD:404699
		PH_Osh1p_Osh2p_yeast	289..391	CDD:241446
		Oxysterol_BP	897..1268	CDD:395990	150/425 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm46714
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840