DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and Osbpl1a

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_997413.2	Gene:	Osbpl1a / 64291	MGIID:	1927551	Length:	950	Species:	Mus musculus

Alignment Length:	451	Identity:	233/451 - (51%)
Similarity:	293/451 - (64%)	Gaps:	39/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEH 76
            ||.||:.|.||.:.|||:||:.|||.:||||||||:.||||||||||.||||:..|:.:|:....
Mouse   534 RTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSD 598

  Fly    77 PADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPPVSAFHAE-- 137
            |.:||:.||||||||:||.|||.||||||||||||||.:.|  :|::.||||||||:||||||
Mouse   599 PVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGL 663

  Fly   138 SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKM 202
            :.||.|||:|.||:||||||||..||||:|:|....||:|:|||..|||||||||:|||||||.:
Mouse   664 NNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 728

  Fly   203 EITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQ 267
            ||.||.||....|.||..|...|.||:|||:::|.|:..|..|||||||.:......::..:
Mouse   729 EIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAY--- 790

  Fly   268 GTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIP 332
              :|||              .|....|.||.::.|.::  ||..|       :|.|:|.:.  ||
Mouse   791 --KKND--------------KKNTEEKKNSKQTSSSEE--SDEMP-------VPDSESVFI--IP 828

  Fly   333 DSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCP-TDSRLRPDILHLEEGNLDGAS 396
            .|..||...|||.|.::.|.||.||:.||.:|..|:   ::.| ||.||||||..:|.|.:|.||
Mouse   829 GSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEME---SVIPKTDCRLRPDIRAMENGEIDLAS 890

  Fly   397 KEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNTDTIF 457
            :||.|||||||..||.| |.:.:||..|||....||::...||:|||.||||.|.|...|:
Mouse   891 EEKKRLEEKQRAARKNR-SKSEEDWKTRWFHQGPNPYSGAQDWIYSGSYWDRNYFNLPDIY 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	216/419 (52%)
Osbpl1a	NP_997413.2	Interaction with RAB7A. /evidence=ECO:0000250	1..237
		Ank_2	10..111	CDD:372319
		ANKYR	<38..208	CDD:223738
		ANK repeat	43..78	CDD:293786
		ANK repeat	80..111	CDD:293786
		ANK repeat	175..206	CDD:293786
		PH_ORP1	229..352	CDD:270102
		FFAT. /evidence=ECO:0000250\|UniProtKB:Q9BXW6	469..483
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..530
		Oxysterol_BP	548..940	CDD:366530	220/425 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..821		9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844878
Domainoid	1	1.000	422	1.000	Domainoid score	I633
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84746
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166926at33208
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm43004
orthoMCL	1	0.900	-	-		OOG6_103876
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X1685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.830