DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and osbpl1a

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_009294603.1	Gene:	osbpl1a / 565503	ZFINID:	ZDB-GENE-050208-657	Length:	972	Species:	Danio rerio

Alignment Length:	459	Identity:	238/459 - (51%)
Similarity:	293/459 - (63%)	Gaps:	49/459 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEH 76
            ||.|||.|.||.:.|||:||:.|||.:||||||||:.||||||||||.||||:..|:.:|...|:
Zfish   550 RTSLPAPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHQANSSEN 614

  Fly    77 PADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKG--DYRIVCEQVSHHPPVSAFHAE-- 137
            ..:|||.||||||||:||.|||.||||||||||||||.:.  |:|::.||||||||:||||||
Zfish   615 SIERMKCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLDFRLISEQVSHHPPISAFHAEGL 679

  Fly   138 SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKM 202
            .|:|.|||:|.||:||||||||..|||.:|:|.||.||:|:|||..|||||||||:|||||||.:
Zfish   680 QKNFVFHGSIYPKLKFWGKSVEAEPKGIITLELPKHNEAYTWTNPTCCVHNIIVGQLWIEQYGNV 744

  Fly   203 EITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQ 267
            |:.||.||....|.||..|...|.||:|||::.|.|:..:..|||||||.:......::     :
Zfish   745 EVINHRTGEKCCLNFKPCGLFGKELHKVEGYILDKSKKKVCVLYGKWTECMYLVDPATF-----E 804

  Fly   268 GTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLD-I 331
            ..:|||          ||...:..|.|         |..||||....:..||        ||: |
Zfish   805 THKKND----------KKASEEKKSSK---------QSQSSDSEETPQPGGD--------SLEVI 842

  Fly   332 PDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCP-TDSRLRPDILHLEEGNLDGA 395
            |.|..||...|||:|.::.|.||.||||||.:|..::   ::.| |||||||||..:|.|::|.|
Zfish   843 PGSQLLWRIAPRPANSAQMYSFTSFALQLNELDKEIE---SVIPKTDSRLRPDIRAMENGDIDMA 904

  Fly   396 SKEKTRLEEKQRHTRKQRKSTNSDDW-------SPRWFKYATNPHTKIDDWLYSGGYWDRKYDNT 453
            |:||.|||||||..||.| |.:.|:|       .||||....|||....|||:|..||||.|...
Zfish   905 SEEKKRLEEKQRAARKNR-SKSDDEWKARNIASGPRWFHQGPNPHNGSQDWLFSNSYWDRDYSQV 968

  Fly   454 DTIF 457
            ..|:
Zfish   969 PDIY 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	222/427 (52%)
osbpl1a	XP_009294603.1	ANK	44..216	CDD:238125
		ANK repeat	48..79	CDD:293786
		ANK repeat	81..174	CDD:293786
		Ank_5	112..>237	CDD:330893
		ANK repeat	176..207	CDD:293786
		PH_ORP1	232..356	CDD:270102
		Oxysterol_BP	564..956	CDD:307410	222/427 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589791
Domainoid	1	1.000	422	1.000	Domainoid score	I607
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84746
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1634
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166926at33208
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm25134
orthoMCL	1	0.900	-	-		OOG6_103876
Panther	1	1.100	-	-	O	PTHR10972
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.990