DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3860 and osbp2b

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_021331891.1	Gene:	osbp2b / 561797	ZFINID:	ZDB-GENE-060526-3	Length:	822	Species:	Danio rerio

Alignment Length:	452	Identity:	168/452 - (37%)
Similarity:	228/452 - (50%)	Gaps:	77/452 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ISRK---EVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEHPADRM 81
            ||.|   .:::|:|:||||||:||||.|||..|||||.||||.|.:||.:||.:||:.|:..::|
Zfish   423 ISEKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDKAARCENSLEQM 487

  Fly    82 KYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD---YRIVCEQVSHHPPVSAFHAES-KDFK 142
            ..||||:||:.::...|..|||||||||||||.:.:   ||.:|||||||||.:|.|..| :.:.
Zfish   488 CLVAAFSVSSYSTTVHRTAKPFNPLLGETYELDRLEEFGYRSLCEQVSHHPPAAAHHVVSQRGWS 552

  Fly   143 FHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKMEITNH 207
            ....|:...||.||.:.:.|.|.:.::|......|.|..|...|||||||:|||:|.|.::|.||
Zfish   553 LWQEITIASKFRGKYLSIMPLGAIHLQFHASGNHYVWRKVTSTVHNIIVGKLWIDQSGDIDIVNH 617

  Fly   208 ATGHVASLTFKSAGSGAKNLHR-VEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQGTRK 271
            .|.....|.|......::.:.| |.|.|.|:.....|.|.|.|.|  |..||:     :.|.:|.
Zfish   618 RTKETCQLKFSPYSYFSREVPRKVTGVVMDSDGQANYILSGTWDE--KMESAK-----IVQSSRG 675

  Fly   272 NDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIPDSTT 336
            :    .|..|..|.::..|:                             ||             .
Zfish   676 S----SSSEGKQKTVYQTLS-----------------------------PK-------------L 694

  Fly   337 LWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLEEGNLDGASKEKTR 401
            ||...|.|.|....|.|:..||.||..:..:.      .||||||||...:|.|..|.|:.||.|
Zfish   695 LWKKYPLPENAENMYYFSSLALTLNEEEDGVS------ITDSRLRPDQRLMEAGRWDEANAEKQR 753

  Fly   402 LEEKQRHTRKQRKSTNS---------DDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNTD 454
            ||||||..|::|::..|         :.:.|.||...|:..|..:.::|.||||:.| |..|
Zfish   754 LEEKQRAVRRRREAEASRAIDEGEDFEGYKPLWFHQTTDEMTGENIFVYKGGYWEAK-DRQD 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	157/428 (37%)
osbp2b	XP_021331891.1	PH_OSBP_ORP4	73..168	CDD:270101
osbp2b	XP_021331891.1	Oxysterol_BP	432..802	CDD:307410	157/428 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840