DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and osbpl2a

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_005162397.1	Gene:	osbpl2a / 557483	ZFINID:	ZDB-GENE-091116-46	Length:	467	Species:	Danio rerio

Alignment Length:	450	Identity:	220/450 - (48%)
Similarity:	287/450 - (63%)	Gaps:	36/450 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEH 76
            ||.|||.|.||.:.|:|..||.|||.:|||||||::.|||||||||:.||||:..|:.:|.....
Zfish    50 RTTLPAPMFSRNDFSVWGFLKKCIGMELSKITMPIVFNEPLSFLQRITEYMEHTYLIHKACTLSD 114

  Fly    77 PADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPPVSAFHAES- 138
            ..:||::||||||||:||.|:|.|||||||||||:||.:.|  ||::.||||||||:|||:|||
Zfish   115 SIERMQFVAAFAVSAVASQWDRTGKPFNPLLGETFELTREDEGYRMISEQVSHHPPISAFYAESL 179

  Fly   139 -KDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKM 202
             :||.|||:|.||:||||||||..||||:|:|..|..|:|:|||..|||||:|:|:|||||||.:
Zfish   180 NQDFSFHGSIYPKLKFWGKSVEAEPKGTMTLELSKHREAYTWTNPMCCVHNVILGKLWIEQYGTV 244

  Fly   203 EITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQ 267
            ||.||:||....|.||..|...|.||||||.::|.|:...:.:||||||.:.....:.|     :
Zfish   245 EIVNHSTGDKCVLNFKPCGMFGKELHRVEGHIQDKSKKKHWVMYGKWTECMYSIEPKVY-----E 304

  Fly   268 GTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIP 332
            ..:|.:...|   |..||                ..||..:..    |...::|......:: ||
Zfish   305 ANKKAEKKSG---GESKK----------------HKQDQGTGG----EDADEMPDVQETVTM-IP 345

  Fly   333 DSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLEEGNLDGASK 397
            .|..||...|||...:|.|.||:||:.||.::..|..  .|.|||.||||||..:|.|::|.||:
Zfish   346 GSKLLWRVAPRPPQSTEMYNFTNFAMTLNELEPGMTE--VLAPTDCRLRPDIRAMENGDIDSASR 408

  Fly   398 EKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNTDTIF 457
            ||.|||||||..|::| :.:.:|||.|||:...||:|...||:|.|||:||:|.....|:
Zfish   409 EKERLEEKQRAARRER-AKDEEDWSTRWFQQGNNPYTGTADWIYKGGYFDRRYSELPDIY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	204/418 (49%)
osbpl2a	XP_005162397.1	Oxysterol_BP	64..451	CDD:279564	204/418 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589789
Domainoid	1	1.000	422	1.000	Domainoid score	I607
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1634
OMA	1	1.010	-	-		QHG54233
OrthoDB	1	1.010	-	-		D166926at33208
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm25134
orthoMCL	1	0.900	-	-		OOG6_103876
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X1685
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940