DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and Osbp

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_477271.1	Gene:	Osbp / 42985	FlyBaseID:	FBgn0020626	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	165/492 - (33%)
Similarity:	236/492 - (47%)	Gaps:	117/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGDYAEHVERTELPA--------------TMISRKE----------VSIWAILKNCIGKDLSKIT 43
            :||..:.|::. |||              .:|.::.          :|:|.|:|||||||||||.
  Fly   353 QGDDDDDVDKA-LPAKESTDSIYGRNWNPDLIKKRRDRVPDKPNHPISLWGIMKNCIGKDLSKIP 416

  Fly    44 MPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLG 108
            ||:..|||||.||||.|..||.::|..||..:...:::.|:|||.|||.|:...|.|||||||||
  Fly   417 MPINFNEPLSMLQRLVEDYEYTEILDYAATCQDECEQLAYIAAFTVSAYATTTNRTGKPFNPLLG 481

  Fly   109 ETYELQKGD---YRIVCEQVSHHPPVSAFHAESKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEF 170
            ||||..:.|   :|.:.|||||||||:|.|.|||::......|...||.||.|::||.|.|.|:|
  Fly   482 ETYECDRMDDYGWRCLAEQVSHHPPVAALHCESKNWTCWQEFSMTSKFRGKYVQINPLGGVYVQF 546

  Fly   171 PKWNESYSWTNVNCCVHNIIVGRLWIEQYGKMEI--TNHATGHVASLTFKSAGSGAKNLHR-VEG 232
            |.....|||..|...|:|||||:||::|:|:|||  :..|.||...|.|......::::.| |:|
  Fly   547 PNSGRRYSWRKVTTTVNNIIVGKLWVDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKG 611

  Fly   233 FVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNS 297
            .|.:......:.:.|.|
  Fly   612 VVMNKDNEVKWVVRGTW------------------------------------------------ 628

  Fly   298 FRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIPDSTT-----LWSCKPRPSNCSEYYQFTHFA 357
                   |:..:..|.::..|         |:..|..||     .|..:|.|.:..::|.||..|
  Fly   629 -------DMKIEIAPVLKTSG---------SVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLA 677

  Fly   358 LQLNAMDSNMKPPLTLCPTDSRLRPDILHLEEGNLDGASKEKTRLEEKQRHTRKQRKSTNSDD-- 420
            .|||..:..      :.|||||||||...:|:|:.|.::|||.||||||| |.::|:...:::
  Fly   678 CQLNEEEEG------VAPTDSRLRPDQRLMEQGDWDESNKEKLRLEEKQR-TERRRRENEAEEAA 735

  Fly   421 --------WSPRWFKYATNPHTKIDDWLYSGGYWDRK 449
                    :.|.|||......::....::...||:.|
  Fly   736 AEGRPYPAYEPMWFKREKEEGSEEYVHVFKNTYWEAK 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	155/435 (36%)
Osbp	NP_477271.1	PH	15..107	CDD:278594
		PH_OSBP_ORP4	17..113	CDD:270101
		Oxysterol_BP	399..764	CDD:279564	155/435 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460435
Domainoid	1	1.000	260	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_KOG1737
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100030at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.880