DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and Osbp2

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_038947935.1	Gene:	Osbp2 / 305475	RGDID:	1310505	Length:	974	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	162/445 - (36%)
Similarity:	213/445 - (47%)	Gaps:	86/445 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEHPADRMKYVAAFAV 89
            :::|:|:|||||::||:|.|||..|||||.||||.|.:||..||.:|.......::|..||||:|
  Rat   584 LNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVAAFSV 648

  Fly    90 SALASNWERLGKPFNPLLGETYELQKGD---YRIVCEQVSHHPPVSAFHAESKDFKFHG-----T 146
            |:.::...|:.|||||:||||:||.:.:   .|.:|||||||||.:|.|..||    ||     .
  Rat   649 SSYSTTVHRIAKPFNPMLGETFELDRLEDMGLRSLCEQVSHHPPSAAHHVFSK----HGWSLWQE 709

  Fly   147 ISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKMEITNHATGH 211
            |:...||.||.:.:.|.|.:.:||......|.|......|||||||:|||:|.|.:||.||.|..
  Rat   710 ITIASKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTKD 774

  Fly   212 VASLTFKSAGSGAKNLHR-VEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQGTRKNDDY 275
            ...|.|......:|...| |.|.|.|:.....|.|.|.|.|.::|...                .
  Rat   775 RCQLKFVPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKI----------------V 823

  Fly   276 DGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIPDSTTLWSC 340
            ..||                           |||.           |..:.|. .:| :..||..
  Rat   824 HSSP---------------------------SSDG-----------KQKTVYQ-TLP-AKLLWRK 848

  Fly   341 KPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLEEGNLDGASKEKTRLEEK 405
            .|.|.|....|.|:..||.||..:..      :.|||||||||...:|.|..|.|:.||.|||||
  Rat   849 YPLPENAENMYYFSELALTLNEQEEG------VAPTDSRLRPDQRLMERGRWDEANTEKQRLEEK 907

  Fly   406 QRHTRKQR-----------KSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRK 449
            ||..|::|           :...||.:||.||:...:|.|.....:|.||||:.|
  Rat   908 QRLNRRRRLESCTAGCGGEEEKESDGYSPLWFEKRLDPLTGEMACIYKGGYWEAK 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	156/434 (36%)
Osbp2	XP_038947935.1	PHA03247	<25..161	CDD:223021
		PH_OSBP_ORP4	170..278	CDD:270101
		Oxysterol_BP	585..960	CDD:395990	160/440 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810