DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3860 and Osbpl2

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001013097.1	Gene:	Osbpl2 / 296461	RGDID:	1311312	Length:	483	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	225/459 - (49%)
Similarity:	291/459 - (63%)	Gaps:	32/459 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EGDYAEHVERTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQL 67
            |....:|  ||.|||.|.:|.:.|:|:|||.|||.:|||||||:..|||||||||:.||||:..|
  Rat    53 ENGIQKH--RTALPAPMFTRSDFSVWSILKKCIGLELSKITMPIAFNEPLSFLQRITEYMEHVYL 115

  Fly    68 LTEAAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPP 130
            :..|:.|..|.:||:.||||||||:||.|||.||||||||||||||.:.|  :|.:.||||||||
  Rat   116 IHRASNQSQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPP 180

  Fly   131 VSAFHAE--SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGR 193
            :|||::|  ::||.|||:|.||:||||||||..|:||:|:|..|.||:|:|||..|||||:|:|:
  Rat   181 ISAFYSEGLNQDFMFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQ 245

  Fly   194 LWIEQYGKMEITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSA 258
            |||||||.:||.||.||....|.||..|...|.||||||:::|.:...|:.:||||||.:.....
  Rat   246 LWIEQYGIVEILNHRTGDKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFIMYGKWTECLWGIDP 310

  Fly   259 ESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKS 323
            .||..|.||..|.:.......:..|:|                    |:||  .|.....|:|.:
  Rat   311 VSYESFKKQEKRGDHARKAKSDDAPEK--------------------VNSD--VPGNMADDVPVA 353

  Fly   324 DSAYSLDIPDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRPDILHLE 388
            .....: ||.|..||....||.|.::.|.||.|.:.||.::|.|:.  ||.|||.||||||..:|
  Rat   354 QETVQV-IPGSKLLWRINSRPPNSAQMYNFTSFTVSLNELESGMEK--TLPPTDCRLRPDIRGME 415

  Fly   389 EGNLDGASKEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNT 453
            .||:|.||:||.|||||||..||:|....: :|..|||....||:|...||||:|.|::|.:.:.
  Rat   416 NGNMDLASQEKERLEEKQREARKERAKEEA-EWRTRWFSPGNNPYTGAPDWLYAGHYFERNFSDC 479

  Fly   454 DTIF 457
            ..|:
  Rat   480 PDIY 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	210/418 (50%)
Osbpl2	NP_001013097.1	Oxysterol_BP	74..473	CDD:395990	214/424 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348345
Domainoid	1	1.000	423	1.000	Domainoid score	I603
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1638
OMA	1	1.010	-	-		QHG54233
OrthoDB	1	1.010	-	-		D166926at33208
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm45068
orthoMCL	1	0.900	-	-		OOG6_103876
Panther	1	1.100	-	-	LDO	PTHR10972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1685
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910