DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3860 and OSBPL1A

DIOPT Version :9

Sequence 1:	NP_001286802.1	Gene:	CG3860 / 37825	FlyBaseID:	FBgn0034951	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_016881019.1	Gene:	OSBPL1A / 114876	HGNCID:	16398	Length:	968	Species:	Homo sapiens

Alignment Length:	451	Identity:	232/451 - (51%)
Similarity:	293/451 - (64%)	Gaps:	39/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RTELPATMISRKEVSIWAILKNCIGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTEAAQQEH 76
            ||.||:.|.||.:.|||:||:.|||.:||||||||:.||||||||||.||||:..|:.:|:....
Human   552 RTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSD 616

  Fly    77 PADRMKYVAAFAVSALASNWERLGKPFNPLLGETYELQKGD--YRIVCEQVSHHPPVSAFHAE-- 137
            |.:||:.||||||||:||.|||.||||||||||||||.:.|  :|::.||||||||:||||||
Human   617 PVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGL 681

  Fly   138 SKDFKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNIIVGRLWIEQYGKM 202
            :.||.|||:|.||:||||||||..||||:|:|..:.||:|:|||..|||||||||:|||||||.:
Human   682 NNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNV 746

  Fly   203 EITNHATGHVASLTFKSAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEFIKCCSAESYVQFLKQ 267
            ||.||.||....|.||..|...|.||:|||:::|.|:..|..|||||||.:......::..:
Human   747 EIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAY--- 808

  Fly   268 GTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQEGDIPKSDSAYSLDIP 332
              :|||         .|....|.||.::::...|       |..|       :|.|:|.:.  ||
Human   809 --KKND---------KKNTEEKKNSKQMSTSEEL-------DEMP-------VPDSESVFI--IP 846

  Fly   333 DSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCP-TDSRLRPDILHLEEGNLDGAS 396
            .|..||...|||.|.::.|.||.||:.||.:|.:|:   ::.| ||.||||||..:|.|.:|.||
Human   847 GSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDME---SVIPKTDCRLRPDIRAMENGEIDQAS 908

  Fly   397 KEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWDRKYDNTDTIF 457
            :||.|||||||..||.| |.:.:||..|||....||:....||:|||.||||.|.|...|:
Human   909 EEKKRLEEKQRAARKNR-SKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3860	NP_001286802.1	Oxysterol_BP	26..441	CDD:279564	215/419 (51%)
OSBPL1A	XP_016881019.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154602
Domainoid	1	1.000	423	1.000	Domainoid score	I622
eggNOG	1	0.900	-	-		E1_KOG1737
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84746
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1714
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D166926at33208
OrthoFinder	1	1.000	-	-		FOG0000898
OrthoInspector	1	1.000	-	-		otm40933
orthoMCL	1	0.900	-	-		OOG6_103876
Panther	1	1.100	-	-	O	PTHR10972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3013
SonicParanoid	1	1.000	-	-		X1685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830