Protein Alignment Pask and MARK4

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001186796.1
• Gene: MARK4 / 57787
• HGNCID: 13538
• Length: 752
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 88/290 - (30%)
• Similarity: 152/290 - (52%)
• Gaps: 22/290 - (7%)

  Fly   558 SLVSKYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRD 622
            |:.|..|::.::|:    |..:|.||:|.:..|.:|..      ::|...:..|:..:..:....
Human    45 SIASCPEEQPHVGN----YRLLRTIGKGNFAKVKLARH------ILTGREVAIKIIDKTQLNPSS 99

  Fly   623 CKEVPIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFR 687
            .:::..|:.:::.|||.|||.:.:|.|.:....|||| :.|..:::.::.....|.||.....||
Human   100 LQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVME-YASAGEVFDYLVSHGRMKEKEARAKFR 163

  Fly   688 QVADAVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLA 752
            |:..||:|.|::.|:|||:|.||:::|....||:.|||.:.....|....||.|:..|.:||:..
Human   164 QIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ 228

  Fly   753 GNRYVGPELEIWALGVTLYVLMFFENPFID------VEETLKAEIQIPKAVSEQLSRLLSSMLNK 811
            |.:|.|||::||:|||.||.|:....||..      .|..|:.:.::|..:|.....:|...|..
Human   229 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVL 293

  Fly   812 DPKYRCTMHQLITDPWLT-----QEVNPST 836
            :|..|||:.|::.|.|:.     :|:.|.|
Human   294 NPAKRCTLEQIMKDKWINIGYEGEELKPYT 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	80/258 (31%)
MARK4	NP_001186796.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		STKc_MARK	58..310	CDD:270974	80/262 (31%)
		UBA_MARK3_4	328..370	CDD:270590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..614
		MARK4_C	654..752	CDD:213382