Protein Alignment Pask and PRKAA2

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_006243.2
• Gene: PRKAA2 / 5563
• HGNCID: 9377
• Length: 552
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 85/280 - (30%)
• Similarity: 146/280 - (52%)
• Gaps: 17/280 - (6%)

  Fly   562 KYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRDCKEV 626
            |::..:.:|.|....|    :|.|.:|.|.:.........|..|.:.::|:.|..:|     .::
Human     6 KHDGRVKIGHYVLGDT----LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV-----GKI 61

  Fly   627 PIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFRQVAD 691
            ..||..|:...|.:|:.:..|......:.:||| :.||.:|:.:|.:...::|.....:|:|:..
Human    62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVME-YVSGGELFDYICKHGRVEEMEARRLFQQILS 125

  Fly   692 AVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLAGNRY 756
            ||:|.|...::|||:|.||:::|.:...|:.|||.:..|.:|:|..|..|:..|.:|||::|..|
Human   126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190

  Fly   757 VGPELEIWALGVTLYVLMFFENPFIDVE-ETLKAEIQ-----IPKAVSEQLSRLLSSMLNKDPKY 815
            .|||::||:.||.||.|:....||.|.. .||..:|:     ||:.::..::.||..||..||..
Human   191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255

  Fly   816 RCTMHQLITDPWLTQEVNPS 835
            |.|:..:....|..|:: ||
Human   256 RATIKDIREHEWFKQDL-PS 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	78/258 (30%)
PRKAA2	NP_006243.2	STKc_AMPK_alpha	13..268	CDD:270981	80/264 (30%)
		UBA_AID_AAPK2	285..349	CDD:270587
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376
		AMPKA2_C	395..550	CDD:213385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..521