Protein Alignment Pask and Sik2

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: XP_061497123.1
• Gene: Sik2 / 4577135
• VectorBaseID: AGAMI1_012952
• Length: 1425
• Species: Anopheles gambiae
• Alignment Length: 694
• Identity: 147/694 - (21%)
• Similarity: 262/694 - (37%)
• Gaps: 165/694 - (23%)

  Fly   410 TIDDILTPVNASNSFPADEFEVGSQSQVNESSLDKAKSAS-----TETCDAS-GSNPATRLLSSI 468
            ::..||.|:..|.:..|........:..:.||...|.|.|     :.:|.:| |:.|:..:
Mosquito    20 SVTSILMPMPMSMAAAAAAAAAAPPTSSSSSSSAAAMSVSAAGKPSPSCPSSTGAAPSVAM---- 80

  Fly   469 NGSFVGEAIHADGSVIEVVYSVLLQILPCSNRVYCIWVCRNPSTRLDGEKYN-YANLTSTFNSMA 532
                    :.|..:......:.....:|| |.|.    ....|:.::.:.|: |.:.|:..|..:
Mosquito    81 --------VLAAAAAAATANNTTTNQMPC-NHVQ----TSTSSSSVESDSYHFYHHKTAGPNGGS 132

  Fly   533 STVEQSLGQVI-------------------------KTTAAQNSSRPNSLSLVS----------- 561
            :.|....|...                         :..::....||:::|..:
Mosquito   133 NGVGAGPGSASAGHHGTGGGGGGGVSKGSGRAGTGHEPASSSGMPRPSAVSGSNGGAGNGGGGSG 197

  Fly   562 ---KYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRDC 623
               |.:|.:.:|    :|...:.||:|.:..|.:|...      |||..:..|:..:..:...:.
Mosquito   198 QRVKCKDPIRVG----FYEIEKTIGKGNFAVVKLARHR------ITKNEVAIKIIDKSQLDPGNL 252

  Fly   624 KEVPIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFRQ 688
            ::|..|:.:::.|:|.:::.:..|.|......:|.|....| :::.:|.:...::|:.....|.|
Mosquito   253 QKVYREVEIMKRLDHPHVIKLYQVMETQSMIYIVSEYASQG-EIFDYIAKYGRLNERAARNKFWQ 316

  Fly   689 VADAVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLAG 753
            :..||.|.|.:.|:|||:|.||:::|....||:.|||.:.|.::|:..:|:.|:..|.:|||..|
Mosquito   317 ILSAVEYCHNKGIVHRDLKAENLLLDSKMDIKIADFGFSNFYKKGELLATWCGSPPYAAPEVFEG 381

  Fly   754 NRYVGPELEIWALGVTLYVLMFFENPFIDV------EETLKAEIQIPKAVSEQLSRLLSSMLNKD 812
            .||.|||::||:|||.||||:....||...      :..|....:||..:|.....|:..||..|
Mosquito   382 KRYTGPEIDIWSLGVVLYVLVCGALPFDGSSLQSLRDRVLSGRFRIPFFMSSDCESLIRKMLVLD 446

  Fly   813 PKYRCTMHQLITDPWLTQEV--NPSTFSF---SWIVPCKAHEANPN------------------- 853
            |..|.::.|:....|:..|:  .|...|.   ..:....|.|..||
Mosquito   447 PSRRFSIDQIKRHRWMMVEIIDTPKISSIVINGSVSEVSALETEPNEQILKIMQNLGIDILKTRE 511

  Fly   854 -LYFSGYLYSSTSVLSTISPQESFSHIEESS------IGGSDDARLASHR---------TGHKLC 902
             |....|.:.:...|..:...:|.:...|::      |||.......|.|         ...||.
Mosquito   512 SLKLHSYDHYTAFYLLLLERLKSRTVSHENATTVAGCIGGGKSGMHESQRRRPSNVAEQAMRKLA 576

  Fly   903 VNEAKHNKMDTLYAKQFQLNTSVSNH--------------------------------------- 928
            ::....:...:...|..|:::.::||
Mosquito   577 ISAQHKSDQPSSSPKHQQVSSGLNNHSSETLHGLLSAAQQVGSGVSPALPAMAPGMMLLRDTSIR 641

  Fly   929 ELRVSLPDSSHTEIGGSICSSKSENDIFKNKL-----QPCVSTY 967
            |.:..|.|||:.. |.|..||....|....:|     :.|.|||
Mosquito   642 EQQPVLKDSSYFR-GVSYTSSSGFTDASLYQLASLRERDCSSTY 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	76/258 (29%)
Sik2	XP_061497123.1	None