DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pask and KP78b

DIOPT Version :9

Sequence 1:	NP_611864.1	Gene:	Pask / 37824	FlyBaseID:	FBgn0034950	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	115/449 - (25%)
Similarity:	191/449 - (42%)	Gaps:	108/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 STFNSMASTVEQSLGQVIKTTAAQNSSRPNSLSLVSKYEDELYLGDYSKYYTSIRQIGRGAYGYV 590
            ||..:..|...|::|....::..::|  |...|.|:        |:....|..|:.:|:|.:..|
  Fly    23 STTATPPSAAAQNVGGCFGSSGGRSS--PKFQSYVN--------GNGYGVYKIIKTLGKGNFAKV 77

  Fly   591 NMAFRNSDRLLVITKFILKEKL---CSQFMVKSRDCKEVPIEIHLLQTLNHKNIVSVLDVFENDL 652
            .:|........|..|.|.|..|   ..|.:.:         |:::::.|||.|||.:|.|.|::.
  Fly    78 KLAIHLPTGREVAIKLIDKTALNTIARQKLYR---------EVNIMKKLNHPNIVRLLQVIESER 133

  Fly   653 FYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFRQVADAVNYLHEQKILHRDIKDENIIIDQNF 717
            ...|||| :.||.:|:.::.:...|.|:....:|||:..|:.|.|.:.|:|||:|.||:::||..
  Fly   134 TLYLVME-YVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQM 197

  Fly   718 TIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLAGNRYVGPELEIWALGVTLYVLMFFENPFID 782
            .:|:.|||.:|..|......||.|:..|.:||:..|.:|.|||::.|:|||.||.|:....||..
  Fly   198 KLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDG 262

  Fly   783 V------EETLKAEIQIPKAVSEQLSRLLSSMLNKDPKYRCTMHQLITDPWLT------------ 829
            .      :..|:.:.::|..||.:...|:...|..:|..|.::..::.|.|:.
  Fly   263 TNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPF 327

  Fly   830 QEVNPSTFSFSWIVPCKAHEANPNLYFSGYLYSSTSVLSTI--SPQESFSHIEESSIGGSDDARL 892
            ||           .|...|:.|           ..|:||.:  .|::    :|:|
  Fly   328 QE-----------KPMDLHDVN-----------RLSLLSNMGHKPRD----VEQS---------- 356

  Fly   893 ASHRTGHKLCVNEAKHNKMDTLYAKQFQLNTSVSNHELRVSLPDSSHTEIGGSICSSKS 951
                         .|:.|.|.:|.....|:         |:.|.|       :.||.||
  Fly   357 -------------LKNQKFDDIYCTYMLLD---------VAKPRS-------TACSEKS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS_9	74..169	CDD:290162
		PAS	74..169	CDD:238075
		PAS_9	286..>335	CDD:290162
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	81/261 (31%)
		S_TKc	576..828	CDD:214567	81/260 (31%)
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	81/260 (31%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	81/260 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010