Protein Alignment Pask and Sik2

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 138/580 - (23%)
• Similarity: 232/580 - (40%)
• Gaps: 124/580 - (21%)

  Fly   425 PADEFEVGSQSQVNESSLDK-----AKSASTETCDASG--SNPATRLLSSINGSFVGEAIHADGS 482
            |.|:.:...|.:.||..|||     .::..||...|.|  |:|....|.|
  Fly    24 PEDQKKKQPQHERNEKQLDKPPENLPQNGKTEAKGAEGACSHPPLDALRS--------------- 73

  Fly   483 VIEVVYSVLLQILPCSNRVYCIWVCRNPSTRLDGEKYNYANLTSTFNSMASTVEQSLGQVIKTTA 547
                  ||||.....|..:..|..|:                           :..|.|.:..:.
  Fly    74 ------SVLLDAGAASPSIDAIVACK---------------------------DALLAQKLFASG 105

  Fly   548 AQNSSRPNSLSL-----------VSKYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLL 601
            ..::..|:..|.           :.|.::.:.:|    :|...|.||:|.:..|.:|...
  Fly   106 GGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVG----FYDIERTIGKGNFAVVKLARHR----- 161

  Fly   602 VITKFILKEKLCSQFMVKSRDCKEVPIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMD 666
             |||..:..|:..:..:...:.::|..|:.:::.|.|.:|:.:..|.|......:|.|....| :
  Fly   162 -ITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQG-E 224

  Fly   667 LWTFIERRPLMDEKLGSYIFRQVADAVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSATFME 731
            ::.:|.:...|.|....:.|.|:..||.|.|::.|:|||:|.||:::|.|..||:.|||.:...:
  Fly   225 IFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFK 289

  Fly   732 EGKFFSTFYGTTEYCSPEVLAGNRYVGPELEIWALGVTLYVLMFFENPFIDV------EETLKAE 790
            .|:..:|:.|:..|.:|||..|.:|.|||::||:|||.||||:....||...      :..|...
  Fly   290 PGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGR 354

  Fly   791 IQIPKAVSEQLSRLLSSMLNKDPKYRCTMHQLITDPWLTQEVNPSTFSFSWIVPCKAHEANPNLY 855
            .:||..:|.:...|:..||..:|..|.|:.|:....|:..|:......           |..||
  Fly   355 FRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLI-----------AKYNL- 407

  Fly   856 FSGYLYSSTSVLSTISPQESFSHIEESSIG-GSDDARLASHRTGHKLCVNEAKHNKMDTLYAKQF 919
                   .....:::.|.|....|....:| |||..|.:            .|.|..|.:.|...
  Fly   408 -------GAERQTSVEPSEDILRIMAEYVGIGSDKTRAS------------LKKNTYDHVAAIYL 453

  Fly   920 QLNTSVSNHE-----LRVSLPDSSHTEIGGSICSSKSENDIFKNKLQ---PCVSTYNVVS 971
            .|...||:.:     |..|...|| |.....|.||::::...:.:.|   ..:||.::::
  Fly   454 LLQDRVSHKKEQSNGLGASALASS-TSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILA 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	78/258 (30%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	78/258 (30%)
		UBA_SIK	418..458	CDD:270523	12/51 (24%)