Protein Alignment Pask and SIK3

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001353615.1
• Gene: SIK3 / 23387
• HGNCID: 29165
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 84/285 - (29%)
• Similarity: 141/285 - (49%)
• Gaps: 30/285 - (10%)

  Fly   575 YYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRDCKEVPIEIHLLQTLNHK 639
            ||...|.||:|.:..|..|..      ::||..:..|:..:..:...:.|::..|:.:::.|.|.
Human    65 YYEIDRTIGKGNFAVVKRATH------LVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP 123

  Fly   640 NIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFRQVADAVNYLHEQKILHR 704
            :|:.:..|.|.:....||.| :.||.:::..:.....|.||.....|:|:..||.:.|.:.|:||
Human   124 HIIRLYQVMETERMIYLVTE-YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHR 187

  Fly   705 DIKDENIIIDQNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLAGNRYVGPELEIWALGVT 769
            |:|.||:::|.|..||:.|||.:.....|:...|:.|:..|.:||:..|..|.||:::||:|||.
Human   188 DLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV 252

  Fly   770 LYVLMFFENPFI-DVEETLKAEI-----QIPKAVSEQLSRLLSSMLNKDPKYRCTMHQLITDPWL 828
            ||||:....||. ...:.|:|.:     :||..:|.:...|:..||..||..|.:|.|:....|:
Human   253 LYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWM 317

  Fly   829 TQEVNPSTFSFSWIVPCKAHEANPN 853
                             |..:|:||
Human   318 -----------------KLGDADPN 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	79/258 (31%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	79/258 (31%)
		UBA_SIK3	346..390	CDD:270593