DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pask and prk-2

DIOPT Version :9

Sequence 1:	NP_611864.1	Gene:	Pask / 37824	FlyBaseID:	FBgn0034950	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_497696.2	Gene:	prk-2 / 175437	WormBaseID:	WBGene00004183	Length:	441	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	115/407 - (28%)
Similarity:	186/407 - (45%)	Gaps:	51/407 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   556 SLSLVSKYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKS 620
            :|.|:...|.......:.|.|....::|||.:|.|..|.|..|..||..|||.:..:.....:..
Worm    11 NLKLLLNGESSRGFSKFKKNYKLKAELGRGGFGVVYRAVRTCDNALVAVKFIERSNVKEWARING 75

  Fly   621 RDCKEVPIEIHLLQTLNH-KNIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSY 684
               ::||:||.:|...:. :.::.:||.:.....:.:|||:....:|::.||:.:..:.|.:..:
Worm    76 ---EQVPMEICMLAKCSKVRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFIKGQGKISEDMARF 137

  Fly   685 IFRQVADAVNYLHEQKILHRDIKDENIIID-QNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSP 748
            :|||:|..|:...:.::||||:|||||:|| ...:.||||||:||.:...: :|.|.||..||.|
Worm   138 LFRQIAVTVHECVQNRVLHRDLKDENIVIDLVTGSTKLIDFGAATVLRRSQ-YSDFQGTRLYCPP 201

  Fly   749 EVLAGNRYVGPELEIWALGVTLYVLMFFENPFIDVEETLKAEIQIP----KAVSEQLSRLLSSML 809
            |....:.|:|.|..:|:|||.||..:....||.:.::...|.:..|    ..||.::..|:|..|
Worm   202 EWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAHLLGPLPFFVPVSAEVKDLISKCL 266

  Fly   810 NKDPKYRCTMHQLITDPWLTQEVNPSTFSFSWIVPCKAHEANPNLYFSGYLYSSTSVLSTISPQE 874
            ..||..||::..::..||:.|:      :.||....|..........|...:|.|  |...|..|
Worm   267 TFDPFQRCSLEAILNHPWVKQQ------TLSWDALTKNKVQKKTSESSDDHHSET--LGDHSETE 323

  Fly   875 SFSHIEESSIG---GSDDARL---ASHRTGHKLCVNEAKHNKMDTLYAK---------------- 917
            .......||:.   ||.|..:   ||....|    |:.|.|..:...||
Worm   324 EDRSPPTSSVSQQPGSADEGVGLSASSSNTH----NQKKPNHKEFRMAKTSLLAPPTSIEMKAAV 384

  Fly   918 -------QFQLNTSVSN 927
                   ||.::|::.|
Worm   385 QASKTPTQFNVHTALKN 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS_9	74..169	CDD:290162
		PAS	74..169	CDD:238075
		PAS_9	286..>335	CDD:290162
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	83/258 (32%)
		S_TKc	576..828	CDD:214567	83/257 (32%)
prk-2	NP_497696.2	STKc_PIM	30..285	CDD:270907	83/258 (32%)
prk-2	NP_497696.2	Pkinase	31..285	CDD:278497	83/257 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14378
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2244
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940