Protein Alignment Pask and Mark3

DIOPT Version :10

• Sequence 1: NP_611864.1
• Gene: Pask / 37824
• FlyBaseID: FBgn0034950
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: XP_006515574.1
• Gene: Mark3 / 17169
• MGIID: 1341865
• Length: 806
• Species: Mus musculus
• Alignment Length: 502
• Identity: 119/502 - (23%)
• Similarity: 215/502 - (42%)
• Gaps: 99/502 - (19%)

  Fly   541 QVIKTTAAQNSSRPNSLSLVSKYEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITK 605
            |.:.:...::.:|..: |:.|..:::.::|:    |..::.||:|.:..|.:|..      ::|.
Mouse    26 QEVTSRTGRSGARCRN-SIASCADEQPHIGN----YRLLKTIGKGNFAKVKLARH------ILTG 79

  Fly   606 FILKEKLCSQFMVKSRDCKEVPIEIHLLQTLNHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWTF 670
            ..:..|:..:..:.....:::..|:.:::.|||.|||.:.:|.|.:....|:|| :.||.:::.:
Mouse    80 REVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIME-YASGGEVFDY 143

  Fly   671 IERRPLMDEKLGSYIFRQVADAVNYLHEQKILHRDIKDENIIIDQNFTIKLIDFGSATFMEEGKF 735
            :.....|.||.....|||:..||.|.|:::|:|||:|.||:::|.:..||:.|||.:.....|..
Mouse   144 LVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSK 208

  Fly   736 FSTFYGTTEYCSPEVLAGNRYVGPELEIWALGVTLYVLMFFENPFIDV------EETLKAEIQIP 794
            ..||.|:..|.:||:..|.:|.|||:::|:|||.||.|:....||...      |..|:.:.:||
Mouse   209 LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273

  Fly   795 KAVSEQLSRLLSSMLNKDPKYRCTMHQLITDPWLT-----QEVNPSTFSFSWIVPCKAHEANPNL 854
            ..:|.....||...|..:|..|.|:.|::.|.|:.     .|:.|.              ..|.|
Mouse   274 FYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPF--------------VEPEL 324

  Fly   855 YFS---------GYLYSSTSVLSTISPQE-------------SFSHIEESSIGGSDDARLAS--- 894
            ..|         |..||...:..::|..:             ..:.::.|....|.:..||.
Mouse   325 DISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRP 389

  Fly   895 ------------HRTGHKLCVNEAKHNKMD----------TLYAKQFQLNTSVSNHELRV-SLPD 936
                        |..|.:...:..|..:..          ..|.|:.|  ||.::.:|:. .:|.
Mouse   390 NSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQ--TSTADSDLKEDGIPS 452

  Fly   937 --SSHTEIGG----------SICSSKSENDIFKNKLQPCVSTYNVVS 971
              ||.:.:||          ....:.::.||.:.|..|.|.:.|..|
Mouse   453 RKSSSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTAS 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS	70..171	CDD:473914
		PAS	182..350	CDD:441804
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	79/258 (31%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	79/262 (30%)
		UBA_MARK3_4	325..367	CDD:270590	5/41 (12%)
		MARK1-3_C	707..804	CDD:213381