DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pask and PIM2

DIOPT Version :9

Sequence 1:	NP_611864.1	Gene:	Pask / 37824	FlyBaseID:	FBgn0034950	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_006866.2	Gene:	PIM2 / 11040	HGNCID:	8987	Length:	311	Species:	Homo sapiens

Alignment Length:	283	Identity:	87/283 - (30%)
Similarity:	143/283 - (50%)	Gaps:	22/283 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 YEDELYLGDYSKYYTSIRQIGRGAYGYVNMAFRNSDRLLVITKFILKEKLCSQFMVKSRDCKEVP 627
            :|.|..||..         :|:|.:|.|....|.:|||.|..|.|.:.::.....:.  |....|
Human    28 FEAEYRLGPL---------LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLS--DSVTCP 81

  Fly   628 IEIHLLQTL----NHKNIVSVLDVFENDLFYQLVMEKHGSGMDLWTFIERRPLMDEKLGSYIFRQ 688
            :|:.||..:    .|..::.:||.||....:.||:|:.....||:.:|..:..:.|......|.|
Human    82 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQ 146

  Fly   689 VADAVNYLHEQKILHRDIKDENIIID-QNFTIKLIDFGSATFMEEGKFFSTFYGTTEYCSPEVLA 752
            |..|:.:.|.:.::|||||||||:|| :....|||||||...:.: :.::.|.||..|..||.::
Human   147 VVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPEWIS 210

  Fly   753 GNRYVGPELEIWALGVTLYVLMFFENPFIDVEETLKAEIQIPKAVSEQLSRLLSSMLNKDPKYRC 817
            .::|......:|:||:.||.::..:.||...:|.|:||:..|..||.....|:...|...|..|.
Human   211 RHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRP 275

  Fly   818 TMHQLITDPWL---TQEV--NPS 835
            ::.:::.|||:   .::|  |||
Human   276 SLEEILLDPWMQTPAEDVPLNPS 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pask	NP_611864.1	PAS_9	74..169	CDD:290162
		PAS	74..169	CDD:238075
		PAS_9	286..>335	CDD:290162
		PAS	286..>325	CDD:238075
		STKc_PASK	575..828	CDD:270906	78/257 (30%)
		S_TKc	576..828	CDD:214567	78/256 (30%)
PIM2	NP_006866.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		STKc_PIM2	31..287	CDD:271003	82/267 (31%)
		S_TKc	32..286	CDD:214567	80/265 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2244
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940