DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phm and pam

DIOPT Version :9

Sequence 1:	NP_477225.1	Gene:	Phm / 37823	FlyBaseID:	FBgn0283509	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_005155561.1	Gene:	pam / 570822	ZFINID:	ZDB-GENE-090313-384	Length:	1010	Species:	Danio rerio

Alignment Length:	347	Identity:	134/347 - (38%)
Similarity:	188/347 - (54%)	Gaps:	38/347 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QNSLYQ-QNLESNSATG----ATASFPFLM------------PNVSPQTPDLYLCTPIKVDPTTT 79
            ||.:|: :..:.||.|.    :....||:|            |.|.|...|.|.|..:.|..:..
Zfish    23 QNHMYRFKRFQENSFTDPNDCSRTRQPFVMSSPYNFSLDIRLPGVVPTESDSYYCMAVPVPTSRE 87

  Fly    80 YYIVGFNPNATMNTAHHMLLYGCGEPGTSKTTWNCGEMNRASQEESASPCGPHSNSQIVYAWARD 144
            .|||.|.|:|:|:|||||:||||..|..::..|:||        :....|  ...::|:|||||:
Zfish    88 AYIVDFVPHASMDTAHHMILYGCKTPYATQGYWDCG--------KELGTC--RDQAKIMYAWARN 142

  Fly   145 AQKLNLPEGVGFKVGKNSPIKYLVLQVHYAHIDKFKDGSTDDSGVFLDYTEEPRKKLAGT-LLLG 208
            |....||:.||||||.::.|.|.|||:||..::.|:|...|.||:.|..|.:|:..:||. |::.
Zfish   143 APPTKLPKDVGFKVGGDTRINYFVLQIHYGDVNNFRDHHRDCSGLSLRMTSKPQPFIAGMYLMMS 207

  Fly   209 TDGQI-PAMKTEHLETACEVNEQKVLHPFAYRVHTHGLGKVVSGYRVRTNSDGEQEWLQLGKRDP 272
            .|..| |..|..:.:.||...... ::|||:|.|||.|||||||||||..     :|.|:|::.|
Zfish   208 VDTLIPPGKKVTNADIACTYTSSP-MYPFAFRTHTHSLGKVVSGYRVRNG-----QWTQIGRQSP 266

  Fly   273 LTPQMFYNTSNTDPIIEGDKIAVRCTMQST-RHRTTKIGPTNEDEMCNFYLMYYVDHGETLNMKF 336
            |.||.||..:||..:.:||.:|.||..... |..||:||.|:.|||||||:|||:|:...:....
Zfish   267 LLPQAFYPATNTIDVKDGDILAARCVFTGEGRTTTTQIGGTSNDEMCNFYIMYYMDNTHAVPYMN 331

  Fly   337 CFSQGAPYYFWSNPDSGLHNIP 358
            |...|:...|.:.|...  |||
Zfish   332 CRDDGSSELFRNIPSEA--NIP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phm	NP_477225.1	Cu2_monooxygen	51..179	CDD:279429	53/139 (38%)
Phm	NP_477225.1	Cu2_monoox_C	201..350	CDD:281675	63/151 (42%)
pam	XP_005155561.1	Cu2_monooxygen	59..176	CDD:279429	50/126 (40%)
		Cu2_monoox_C	199..345	CDD:281675	63/151 (42%)
		NHL_PAL_like	494..803	CDD:271328
		NHL repeat	508..569	CDD:271328
		NHL repeat	575..616	CDD:271328
		NHL repeat	627..665	CDD:271328
		NHL repeat	676..714	CDD:271328
		NHL repeat	723..770	CDD:271328
		NHL repeat	776..802	CDD:271328
		TonB	781..>905	CDD:223880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002923
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910