DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phm and Pam

DIOPT Version :9

Sequence 1:	NP_477225.1	Gene:	Phm / 37823	FlyBaseID:	FBgn0283509	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_017451775.1	Gene:	Pam / 25508	RGDID:	3252	Length:	977	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	130/364 - (35%)
Similarity:	186/364 - (51%)	Gaps:	38/364 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLIGVISVDGLVKEGDYQNSLYQQNLE-----SNSATGATA----------SFPFLMPNVSPQ 62
            ||||:|::::...........|::::..|     ||...|...          :....||.|:|:
  Rat    10 LLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTIGPVTPLDASDFALDIRMPGVTPK 74

  Fly    63 TPDLYLCTPIKVDPTTTYYIVGFNPNATMNTAHHMLLYGCGEPGTSKTTWNCGEMNRASQEESAS 127
            ..|.|.|..:::......:::.|.|.|:|:|.|||||:||..|.::.:.|.|.|          .
  Rat    75 ESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDE----------G 129

  Fly   128 PCGPHSNSQIVYAWARDAQKLNLPEGVGFKVGKNSPIKYLVLQVHYAHIDKFKDGSTDDSGVFLD 192
            .|...:|  |:|||||:|....||:||||:||..:..||.||||||..|..|:|...|.|||.:.
  Rat   130 TCTDKAN--ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSVH 192

  Fly   193 YTEEPRKKLAGT-LLLGTDGQI-PAMKTEHLETACEVNEQKVLHPFAYRVHTHGLGKVVSGYRVR 255
            .|..|:..:||. |::..|..| |..|..:.:.:|:. :...:|.||||||||.|||||||||||
  Rat   193 LTRVPQPLIAGMYLMMSVDTVIPPGEKVVNADISCQY-KMYPMHVFAYRVHTHHLGKVVSGYRVR 256

  Fly   256 TNSDGEQEWLQLGKRDPLTPQMFYNTSNTDPIIEGDKIAVRCTMQST-RHRTTKIGPTNEDEMCN 319
            ..     :|..:|:::|..||.||...:...:..||.:|.||..... |...|.||.|:.|||||
  Rat   257 NG-----QWTLIGRQNPQLPQAFYPVEHPVDVTFGDILAARCVFTGEGRTEATHIGGTSSDEMCN 316

  Fly   320 FYLMYYVDHGETLNMKFCFSQGAPYYFWSNPDSGLHNIP 358
            .|:|||::....|:...|....||..|.:.|...  |||
  Rat   317 LYIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEA--NIP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phm	NP_477225.1	Cu2_monooxygen	51..179	CDD:279429	49/127 (39%)
Phm	NP_477225.1	Cu2_monoox_C	201..350	CDD:281675	59/151 (39%)
Pam	XP_017451775.1	Cu2_monooxygen	64..173	CDD:395859	46/120 (38%)
		Cu2_monoox_C	201..347	CDD:397669	59/151 (39%)
		NHL_PAL_like	503..810	CDD:271328
		NHL repeat	517..578	CDD:271328
		NHL repeat	584..625	CDD:271328
		NHL repeat	636..674	CDD:271328
		NHL repeat	686..724	CDD:271328
		NHL repeat	732..777	CDD:271328
		NHL repeat	783..809	CDD:271328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6726
eggNOG	1	0.900	-	-		E1_KOG3567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002923
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.770