DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phm and Pam

DIOPT Version :9

Sequence 1:	NP_477225.1	Gene:	Phm / 37823	FlyBaseID:	FBgn0283509	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_006529306.1	Gene:	Pam / 18484	MGIID:	97475	Length:	980	Species:	Mus musculus

Alignment Length:	364	Identity:	129/364 - (35%)
Similarity:	185/364 - (50%)	Gaps:	38/364 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLIGVISVDGLVKEGDYQNSLYQQNLE-----SNSATGATA----------SFPFLMPNVSPQ 62
            ||||:|::::...........|::::..|     ||...|.|.          :....||.|:|:
Mouse     9 LLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTTRPITPIDSSDFTLDIRMPGVTPK 73

  Fly    63 TPDLYLCTPIKVDPTTTYYIVGFNPNATMNTAHHMLLYGCGEPGTSKTTWNCGEMNRASQEESAS 127
            ..|.|.|..:::......:::.|.|.|:|:|.|||||:||..|.::.:.|.|.|          .
Mouse    74 ESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDE----------G 128

  Fly   128 PCGPHSNSQIVYAWARDAQKLNLPEGVGFKVGKNSPIKYLVLQVHYAHIDKFKDGSTDDSGVFLD 192
            .|...:|  |:|||||:|....||:||||:||..:..||.||||||..|..|:|...|.|||.|.
Mouse   129 TCTDKAN--ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSLH 191

  Fly   193 YTEEPRKKLAGTLLLGTDGQI--PAMKTEHLETACEVNEQKVLHPFAYRVHTHGLGKVVSGYRVR 255
            .|..|:..:||..|:.:...:  |..|..:.:.:|.. :...:|.||||||||.|||||||||||
Mouse   192 LTRVPQPLIAGMYLMMSVNTVIPPGEKVVNSDISCHY-KMYPMHVFAYRVHTHHLGKVVSGYRVR 255

  Fly   256 TNSDGEQEWLQLGKRDPLTPQMFYNTSNTDPIIEGDKIAVRCTMQST-RHRTTKIGPTNEDEMCN 319
            ..     :|..:|::.|..||.||...:...:..||.:|.||..... |...|.||.|:.|||||
Mouse   256 NG-----QWTLIGRQSPQLPQAFYPVEHPVDVAFGDILAARCVFTGEGRTEATHIGGTSSDEMCN 315

  Fly   320 FYLMYYVDHGETLNMKFCFSQGAPYYFWSNPDSGLHNIP 358
            .|:|||::....::...|....||..|.:.|:..  |||
Mouse   316 LYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPEEA--NIP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phm	NP_477225.1	Cu2_monooxygen	51..179	CDD:279429	49/127 (39%)
Phm	NP_477225.1	Cu2_monoox_C	201..350	CDD:281675	56/151 (37%)
Pam	XP_006529306.1	Cu2_monooxygen	63..172	CDD:395859	46/120 (38%)
		Cu2_monoox_C	200..346	CDD:397669	56/151 (37%)
		NHL_PAL_like	503..810	CDD:271328
		NHL repeat	517..578	CDD:271328
		NHL repeat	584..625	CDD:271328
		NHL repeat	636..674	CDD:271328
		NHL repeat	686..724	CDD:271328
		NHL repeat	732..777	CDD:271328
		NHL repeat	783..809	CDD:271328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6940
eggNOG	1	0.900	-	-		E1_KOG3567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.960964	Normalized mean entropy	S6078
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002923
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2722
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.750