DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phm and pam

DIOPT Version :9

Sequence 1:	NP_477225.1	Gene:	Phm / 37823	FlyBaseID:	FBgn0283509	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001184164.1	Gene:	pam / 100170159	XenbaseID:	XB-GENE-950935	Length:	985	Species:	Xenopus tropicalis

Alignment Length:	379	Identity:	138/379 - (36%)
Similarity:	190/379 - (50%)	Gaps:	57/379 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IAASVGLLLLIGVISVDGLVKEGDYQNSL------------YQQNLE--SNSATGATA------- 50
            :|:.:..||::.:||          |||.            ||::..  ||...|.|.
Frog     1 MASFISSLLVLFLIS----------QNSCYSFRSPLSVFKRYQESTRSLSNDCLGTTRPVMSPGS 55

  Fly    51 ---SFPFLMPNVSPQTPDLYLCTPIKVDPTTTYYIVGFNPNATMNTAHHMLLYGCGEPGTSKTTW 112
               :....||.|:|...|.|||...::......|:|.|.|:|:|:|||||||:||..|.::...|
Frog    56 SDYTLDIRMPGVTPTESDTYLCKSYRLPVDDEAYVVDFRPHASMDTAHHMLLFGCNMPSSTDDYW 120

  Fly   113 NCGEMNRASQEESASPCGPHSNSQIVYAWARDAQKLNLPEGVGFKVGKNSPIKYLVLQVHYAHID 177
            :|          ||..|  ...|.|:||||::|....|||||||:||..|..:|.||||||..:.
Frog   121 DC----------SAGTC--TDKSSIMYAWAKNAPPTKLPEGVGFRVGGKSGNRYFVLQVHYGDVK 173

  Fly   178 KFKDGSTDDSGVFLDYTEEPRKKLAGTLL-LGTDGQI-PAMKTEHLETACEVNEQKVLHPFAYRV 240
            .|:|...|.:||.:..|.|.:..:||..| :..|..| |.:...:.:.||..| :..:|||||||
Frog   174 AFQDKHKDCTGVTVRITPEKQPLIAGIYLSMSVDTVIPPGVDAVNSDIACLYN-RPAIHPFAYRV 237

  Fly   241 HTHGLGKVVSGYRVRTNSDGEQEWLQLGKRDPLTPQMFYNTSNTDPIIEGDKIAVRCTMQSTRHR 305
            |||.||:||||:|||     ..:|..:|::.|..||.||...:...|..||.||.||........
Frog   238 HTHQLGQVVSGFRVR-----HGKWTLIGRQSPQLPQAFYPVEHPLEISPGDIIATRCLFTGKGKT 297

  Fly   306 T-TKIGPTNEDEMCNFYLMYYVDHGETLNMKFCFSQGAPYYFWSNPDSGLHNIP 358
            | |.||.|.:|||||.|:|||:|.....:...|...|.|..|.:.|:  :.|:|
Frog   298 TPTYIGGTAKDEMCNLYIMYYMDAAHASSYMTCVQTGEPKLFQNIPE--IANVP 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phm	NP_477225.1	Cu2_monooxygen	51..179	CDD:279429	53/127 (42%)
Phm	NP_477225.1	Cu2_monoox_C	201..350	CDD:281675	61/151 (40%)
pam	NP_001184164.1	Cu2_monooxygen	60..169	CDD:366454	51/120 (43%)
		Cu2_monoox_C	197..343	CDD:367618	61/151 (40%)
		NHL_PAL_like	503..810	CDD:271328
		NHL repeat	517..578	CDD:271328
		NHL repeat	584..624	CDD:271328
		NHL repeat	635..673	CDD:271328
		NHL repeat	685..723	CDD:271328
		NHL repeat	731..777	CDD:271328
		NHL repeat	783..809	CDD:271328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002923
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2722
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.030