DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and PDLIM1

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_066272.1	Gene:	PDLIM1 / 9124	HGNCID:	2067	Length:	329	Species:	Homo sapiens

Alignment Length:	225	Identity:	39/225 - (17%)
Similarity:	82/225 - (36%)	Gaps:	44/225 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 TTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDSGD-----------------TSS 331
            |..:..:|..|.|....||  ....:||......|..|::..:.:                 |..
Human    34 TPGSKAALANLCIGDVITA--IDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEE 96

  Fly   332 KPKYEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGP--LESRE 394
            ..::..||..|.:.... :.:.||.|      ...:|.:....:....::.:...:.|  |.|.|
Human    97 GKRHPYKMNLASEPQEV-LHIGSAHN------RSAMPFTASPASSTTARVITNQYNNPAGLYSSE 154

  Fly   395 NLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMDNISDI-SPINDREELTEEVMRY 458
            |:|...|..      .::.:..||.:.::...:...|::.::|..|:: ..:.:::||.|...:.
Human   155 NISNFNNAL------ESKTAASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQS 213

  Fly   459 LPYLEVNPSSDGLTLKVESSSLLGKPLNEP 488
            ..:|.:.        ::..|...|.| |:|
Human   214 TSFLVLQ--------EILESEEKGDP-NKP 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684
PDLIM1	NP_066272.1	PDZ_signaling	10..82	CDD:238492	10/49 (20%)
		DUF4749	138..230	CDD:318205	17/105 (16%)
		LIM_CLP36	260..311	CDD:188832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900