DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Sox11

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_445801.1	Gene:	Sox11 / 84046	RGDID:	69351	Length:	395	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	125/430 - (29%)
Similarity:	178/430 - (41%)	Gaps:	120/430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 EMTLSMDGIDS--SLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICER 208
            |..|..|.:|:  ......:.|.::.|.|  |..:|   :.||||||||||||||::|||||.|:
  Rat    11 ESNLPRDALDTEEGEFMACSPVALDESDP--DWCKT---ASGHIKRPMNAFMVWSKIERRKIMEQ 70

  Fly   209 TPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGS----- 268
            :||:|||||||.||:||::|...:|.|:|.|||:||..||.:||:|||||:||....|.:
  Rat    71 SPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKTDPAAKPSAG 135

  Fly   269 LKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQSGSASKRLRNDSGDTSSKP 333
            ..|::.|.|.:|..........|...|  |...||:.::  ...|.:|.|:|.:..|..|.....
  Rat   136 QSPDKSAAGAKAAKGPGKKCAKLKAPA--GKAGAGKAAQ--PGDCGAGKAAKCVFLDDDDEEDDE 196

  Fly   334 KYEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSE 398
            ..|:::...          |.||:                  |.||..||.|...|  :::...:
  Rat   197 DDELQLRPK----------PDADD------------------DDDEPAHSHLLPPP--AQQQPPQ 231

  Fly   399 VVNRF----LPLFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMD-------------NISD----- 441
            ::.|:    :|             :|.|.|...:|...|.|.|             ||:.
  Rat   232 LLRRYSVAKVP-------------ASPTLSSAAESPEGASLYDEVRAGGRLYYSFKNITKQQPPP 283

  Fly   442 ----ISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLNEPVFDSEDNIVNDANL 502
                :||.:.|...|.             ||.|     .||....:..::.:||...|....|
  Rat   284 APPALSPASSRCVSTS-------------SSSG-----SSSGSGAEDADDLMFDLSLNFSQGA-- 328

  Fly   503 HSASHQIP-----------PYVPDSHDCFAEDCGGDSSSH 531
            |||..| |           ..|....|.|:|   |...||
  Rat   329 HSACEQ-PLGAGAAGNLSLSLVDKDLDSFSE---GSLGSH 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	47/70 (67%)
Sox11	NP_445801.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		4/10 (40%)
		SOX-TCF_HMG-box	48..119	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..258		41/190 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..312		10/53 (19%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q7M6Y2	363..395		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342390
Domainoid	1	1.000	106	1.000	Domainoid score	I6444
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm44720
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840