DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and SYNPO2L

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001107605.1	Gene:	SYNPO2L / 79933	HGNCID:	23532	Length:	977	Species:	Homo sapiens

Alignment Length:	662	Identity:	142/662 - (21%)
Similarity:	207/662 - (31%)	Gaps:	220/662 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PNQATTEPPLSL-------RP----GTVPTVPATT----PARPATITIQRRHP----------AP 44
            |.:|...||..|       ||    |..|| ||.:    .|||.|..:|.:.|          ||
Human   429 PPEAAVLPPSPLPAPVASPRPFQPGGGAPT-PAPSIFNRSARPFTPGLQGQRPTTTSVIFRPLAP 492

  Fly    45 KADSTPHTLPPFSPSPSP---ASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAA----- 101
            |..:  .:|...||:|.|   :..|:|.|:.|.|   ..|.|.::...:....|.||.|.
Human   493 KRAN--DSLGGLSPAPPPFLSSQGPTPLPSFTSG---VPSHAPVSGSPSTPRSSGPVTATSSLYI 552

  Fly   102 -APKTPKT-------PEPRSTHTHTHTHSQHFSPPPR-----ESEMDGERSPS-HSGHEMTLSMD 152
             ||..|.|       |.|.|....|.|.|...|.|.|     |:...|..:|. .|..|..:|:.
Human   553 PAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPSARPEAPAPGPGAPEPPSAREQRISVP 617

  Fly   153 GIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEI 217
            ...:.::..:.|          ..||.:...||.                    |.|.:..|.|:
Human   618 AARTGILQEARR----------RGTRKQMFRPGK--------------------EETKNSPNPEL 652

  Fly   218 SK------ELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKY-----------------RPQ 259
            ..      |..|.....|..::....:.||....:..:...:||.                 .|.
Human   653 LSLVQNLDEKPRAGGAESGPEEDALSLGAEACNFMQPVGARSYKTLPHVTPKTPPPMAPKTPPPM 717

  Fly   260 KKQTRSPGSLKPNQDA--DGCEARNDTTNNNNSLTTLAI---------NGTTTAGRKSKRSTSTC 313
            ..:|..|.:.||....  ||..        |.:.::..|         .|...|.|:|:......
Human   718 TPKTPPPVAPKPPSRGLLDGLV--------NGAASSAGIPEPPRLQGRGGELFAKRQSRADRYVV 774

  Fly   314 Q---SGSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQS--SEYLPLS--T 371
            :   ......|.|:.|...|..|.::.         |.:|..|..   |:|..  |.:.|.:  |
Human   775 EGTPGPGLGPRPRSPSPTPSLPPSWKY---------SPNIRAPPP---IAYNPLLSPFFPQAART 827

  Fly   372 LSNADCDEKLHSELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQH---------- 426
            |..|.         |.||            |..|         :.|:.:|...:|
Human   828 LPKAQ---------SQGP------------RATP---------KQGIKALDFMRHQPYQLKTAMF 862

  Fly   427 --NQSDPTAGLMDNISDISPINDREELTEEVMRY---LPYLEVNPSSDGLTLKVESSSLLGKPLN 486
              ::..||.|   .|:..||...|   .:|:.|:   .|    .|:::.|...| .:......|:
Human   863 CFDEVPPTPG---PIASGSPKTAR---VQEIRRFSTPAP----QPTAEPLAPTV-LAPRAATTLD 916

  Fly   487 EPVFDSEDNIVNDANLHSA---SHQIPPYVPDSHDCFAEDCGGDSSSHQVEFEVVRPQTVTMTMT 548
            ||::.:|        |.||   |...||..|.........||         |:|.||:.......
Human   917 EPIWRTE--------LASAPVPSPAPPPEAPRGLGASPSSCG---------FQVARPRFSATRTG 964

  Fly   549 CTLPYGGPDAGH 560
            .......|.|||
Human   965 LQAHVWRPGAGH 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	11/93 (12%)
SYNPO2L	NP_001107605.1	PDZ_signaling	6..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..677		68/283 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..802		18/121 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..950		8/35 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900