DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox14 and TGFB1I1

DIOPT Version :9

Sequence 1:NP_001286801.1 Gene:Sox14 / 37822 FlyBaseID:FBgn0005612 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_001035919.1 Gene:TGFB1I1 / 7041 HGNCID:11767 Length:461 Species:Homo sapiens


Alignment Length:250 Identity:54/250 - (21%)
Similarity:88/250 - (35%) Gaps:50/250 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TTEPPLSLRPGTVPTVPATTPA----RPATITIQRRHPAPKADSTPHTL-PPFSPSP-SPASSPS 67
            |:..|.|..|...|..|.|.|.    :|.|.:.:....:...|....|: .|.||.| :||:.|.
Human    15 TSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPF 79

  Fly    68 PAPAQTPGA----------QKTQSQAAITHPAAVASPSAPVAAAAPKTPKTPEPRSTHTHTHTHS 122
            .:.:...|.          :...:|..||.......||:.||:...|..::.:.:..       |
Human    80 SSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRP-------S 137

  Fly   123 QHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSL----------VFGSARVPVNSSTPYSDAT 177
            ...||.|        ..|..|....||.:|.:.:||          ..|..:.||.|||.....:
Human   138 LPSSPSP--------GLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPS 194

  Fly   178 RTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNA-------EISKELGRRW 225
            ..:....|.:...:.  ::.|.:.||.:..:...|..:       ::...|||.|
Human   195 PPEPTGKGSLDTMLG--LLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAW 247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox14NP_001286801.1 SOX-TCF_HMG-box 186..257 CDD:238684 7/46 (15%)
TGFB1I1NP_001035919.1 Interaction with PTK2B/PYK2 1..240 50/241 (21%)
Transcription activation. /evidence=ECO:0000250 1..200 45/199 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..87 19/71 (27%)
LD motif 1 3..15 53/249 (21%)
Interaction with PTK2/FAK1. /evidence=ECO:0000250 83..136 9/52 (17%)
Paxillin <86..>106 CDD:308898 2/19 (11%)
LD motif 2 92..104 0/11 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..152 11/50 (22%)
LD motif 3 157..168 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 172..205 7/32 (22%)
LD motif 4 203..215 1/13 (8%)
LIM1_Paxillin_like 228..280 CDD:259830 3/19 (16%)
LIM2_Paxillin_like 287..338 CDD:188723
LIM3_Paxillin 346..398 CDD:188793
LIM4_Leupaxin 405..456 CDD:188796
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1703
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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