DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and SRY

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_003131.1	Gene:	SRY / 6736	HGNCID:	11311	Length:	204	Species:	Homo sapiens

Alignment Length:	171	Identity:	59/171 - (34%)
Similarity:	89/171 - (52%)	Gaps:	40/171 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 FGSARVPVNSSTPYSDATR-------------------------TKKHSPGH----IKRPMNAFM 195
            :.||.:.|.:|..||.|.:                         |.::|.|:    :|||||||:
Human     4 YASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFI 68

  Fly   196 VWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQK 260
            |||:.:|||:....|.:.|:||||:||.:|::|::.:|.|:..||:||:.:|..:||||||||::
Human    69 VWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRR 133

  Fly   261 KQTRSPG--SLKPNQDA---------DGCEARNDTTNNNNS 290
            |....|.  ||.|...|         |....|:|.|...:|
Human   134 KAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHS 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	35/74 (47%)
SRY	NP_003131.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000269\|PubMed:15297880	59..136		39/76 (51%)
		SOX-TCF_HMG-box	59..130	CDD:238684	35/70 (50%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:12764225, ECO:0000269\|PubMed:15746192	61..77		11/15 (73%)
		Sufficient for interaction with EP300. /evidence=ECO:0000269\|PubMed:15297880	107..139		15/31 (48%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:15297880	130..136		3/5 (60%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269\|PubMed:15469996	138..155		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..204		59/171 (35%)
		Necessary for interaction with SLC9A3R2. /evidence=ECO:0000269\|PubMed:9054412	198..204
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940