Protein Alignment Sox14 and SOX12

DIOPT Version :10

• Sequence 1: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: NP_008874.2
• Gene: SOX12 / 6666
• HGNCID: 11198
• Length: 315
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 86/273 - (31%)
• Similarity: 121/273 - (44%)
• Gaps: 77/273 - (28%)

  Fly   127 PPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPM 191
            |||..       .|:..|                  ||.|....||           .|||||||
Human    16 PPPGP-------GPAEEG------------------AREPGWCKTP-----------SGHIKRPM 44

  Fly   192 NAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKY 256
            ||||||||.|||||.::.||:|||||||.||||||||...:|.|::.|||:||..||.:||:|||
Human    45 NAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKY 109

  Fly   257 RPQKK--------QTRSPGS------LKPNQDADGCEAR---------------NDTTNNNNSLT 292
            ||:||        :.|.||.      |||.....|...|               :|..:::..|.
Human   110 RPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELL 174

  Fly   293 TLAINGT--------TTAGR----KSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQL 345
            .:.:..|        ..|||    :::|:......|:|:....:.:.....:|:.|.:..:|.:.
Human   175 EVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEE 239

  Fly   346 NSADIILPSADNL 358
            ...:.:....::|
Human   240 GEEETVASGEESL 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	52/74 (70%)
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		11/59 (19%)
		HMG-box_SF	29..116	CDD:469606	58/97 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..288		32/153 (21%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q04890	283..315