DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and SOX12

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_008874.2	Gene:	SOX12 / 6666	HGNCID:	11198	Length:	315	Species:	Homo sapiens

Alignment Length:	273	Identity:	86/273 - (31%)
Similarity:	121/273 - (44%)	Gaps:	77/273 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPM 191
            |||..       .|:..|                  ||.|....||           .|||||||
Human    16 PPPGP-------GPAEEG------------------AREPGWCKTP-----------SGHIKRPM 44

  Fly   192 NAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKY 256
            ||||||||.|||||.::.||:|||||||.||||||||...:|.|::.|||:||..||.:||:|||
Human    45 NAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKY 109

  Fly   257 RPQKK--------QTRSPGS------LKPNQDADGCEAR---------------NDTTNNNNSLT 292
            ||:||        :.|.||.      |||.....|...|               :|..:::..|.
Human   110 RPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELL 174

  Fly   293 TLAINGT--------TTAGR----KSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQL 345
            .:.:..|        ..|||    :::|:......|:|:....:.:.....:|:.|.:..:|.:.
Human   175 EVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEE 239

  Fly   346 NSADIILPSADNL 358
            ...:.:....::|
Human   240 GEEETVASGEESL 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	49/70 (70%)
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		11/59 (19%)
		SOX-TCF_HMG-box	39..110	CDD:238684	49/70 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..288		32/153 (21%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q04890	283..315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148485
Domainoid	1	1.000	109	1.000	Domainoid score	I6341
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm40581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.910