DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and SOX9

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens

Alignment Length:	643	Identity:	144/643 - (22%)
Similarity:	224/643 - (34%)	Gaps:	223/643 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPPF-----------SPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTP 106
            |.||           |.:|||..|...|.:..|....:.::           .:.|.....||
Human     4 LDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTE-----------NTRPQENTFPK-- 55

  Fly   107 KTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSST 171
                               ..|..:.|.:.::.|......::..:.|.|.:||  ...|.||.|:
Human    56 -------------------GEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLV--PMPVRVNGSS 99

  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236
                     |:.| |:||||||||||:|..|||:.::.|.|||||:||.||:.|:||::.:|:|:
Human   100 ---------KNKP-HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPF 154

  Fly   237 IIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT 301
            :.|||:||..|..::|:|||:|::::     |:| |..|:..||...|..:.|::
Human   155 VEEAERLRVQHKKDHPDYKYQPRRRK-----SVK-NGQAEAEEATEQTHISPNAI---------- 203

  Fly   302 AGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEY 366
                             .|.|:.||..:||              ..:::..|..
Human   204 -----------------FKALQADSPHSSS--------------GMSEVHSPGE----------- 226

  Fly   367 LPLSTLSNADCDEKLHSELSSGP--------LESRENLSEVVNRFLPLFLGGNE------DSQLG 417
                           ||..|.||        .:.:...:::.....||..||.:      |..:|
Human   227 ---------------HSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIG 276

  Fly   418 VSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVN-----PSSDGLTLKVES 477
            ..|               .|.||:|.        |.:|..:..||..|     |::.|......|
Human   277 ELS---------------SDVISNIE--------TFDVNEFDQYLPPNGHPGVPATHGQVTYTGS 318

  Fly   478 ---SSLLGKPLNEPVFDSEDNIVNDANLHSASH-------------QIPPYVPDSHDCFAEDCGG 526
               ||....|.                  ||.|             |.||..|.:..  |.....
Human   319 YGISSTAATPA------------------SAGHVWMSKQQAPPPPPQQPPQAPPAPQ--APPQPQ 363

  Fly   527 DSSSHQVEFEVVRPQTVTMTMTCTLPYGGPDAGHTTFQADDFNAIPSAAEDSECSILTTSNSP-Q 590
            .:...|......:||..|:|   ||......:..|..:.:..:  ||...:.:      .:|| |
Human   364 AAPPQQPAAPPQQPQAHTLT---TLSSEPGQSQRTHIKTEQLS--PSHYSEQQ------QHSPQQ 417

  Fly   591 IGFNGSSFVEADAIGSTCTYAQQDYTGSVIETHNDLNYAAH-DNNGALLAYTFEDLPP 647
            |.::..:...........|.:|.|||    :..|..:|.:| ...|..|..||..:.|
Human   418 IAYSPFNLPHYSPSYPPITRSQYDYT----DHQNSSSYYSHAAGQGTGLYSTFTYMNP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	39/70 (56%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		15/94 (16%)
		Sox_N	22..94	CDD:403592	16/105 (15%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		11/50 (22%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		11/50 (22%)
		SOX-TCF_HMG-box	104..174	CDD:238684	38/69 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		32/185 (17%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		22/131 (17%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284		3/23 (13%)
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415		18/97 (19%)
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509		20/90 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740