DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and SOX4

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_003098.1	Gene:	SOX4 / 6659	HGNCID:	11200	Length:	474	Species:	Homo sapiens

Alignment Length:	522	Identity:	147/522 - (28%)
Similarity:	218/522 - (41%)	Gaps:	112/522 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 ESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNAFM 195
            |:.:.||.|.|.:|.|:     ||.||...||..    |:...:|.....|...|||||||||||
Human    12 EALLAGESSDSGAGLEL-----GIASSPTPGSTA----STGGKADDPSWCKTPSGHIKRPMNAFM 67

  Fly   196 VWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLHMIEYPNYKYRPQK 260
            ||||:|||||.|::||:|||||||.||:||:||...||.|:|.|||:||..||.:||:|||||:|
Human    68 VWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRK 132

  Fly   261 K--------QTRSPGSLKPNQDAD-----GCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTST 312
            |        .:.:..|.||.:..|     |...........:|.......|.:..|..||    .
Human   133 KVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGASGGGANSK----P 193

  Fly   313 CQSGSASKRLRNDSGDTSSKPKYEVKME----------------SAEQLNSADIILP---SADNL 358
            .|..|...::...:|...|||..::.:.                :|||..:| .:||   :||:.
Human   194 AQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAA-ALLPLGAAADHH 257

  Fly   359 ISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQ 423
            ..|::......::.|:|       :..|:......::|:|...:.:.|| ||     ||.|
Human   258 SLYKARTPSASASASSA-------ASASAALAAPGKHLAEKKVKRVYLF-GG-----LGTS---- 305

  Fly   424 SQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGK--PLN 486
                 |.|..|:........|:...||                  :|.....::.||.|:  ..:
Human   306 -----SSPVGGVGAGADPSDPLGLYEE------------------EGAGCSPDAPSLSGRSSAAS 347

  Fly   487 EPVFD-SEDNIVNDANLHSASHQIPPYVP-------DSHDCFAEDCGGDSSSHQVEFEV--VRPQ 541
            .|... |..:....|:|.:|| ..|...|       .||...:...|..||..:.|.::  :.|.
Human   348 SPAAGRSPADHRGYASLRAAS-PAPSSAPSHASSSASSHSSSSSSSGSSSSDDEFEDDLLDLNPS 411

  Fly   542 TVTMTMTCTLPYGGPDAGHTTFQAD-DFNAIPSAAEDSECSILTTSNSPQIGFNGSSFVEADAIG 605
            :...:|:.     |..:..:....| |||..|.:....|.....|   |::    |..:..|.:.
Human   412 SNFESMSL-----GSFSSSSALDRDLDFNFEPGSGSHFEFPDYCT---PEV----SEMISGDWLE 464

  Fly   606 ST 607
            |:
Human   465 SS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	50/70 (71%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		16/54 (30%)
		SOX-TCF_HMG-box	58..129	CDD:238684	50/70 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..228		21/103 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..286		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..416		28/141 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148493
Domainoid	1	1.000	109	1.000	Domainoid score	I6341
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm40581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.790