DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox14 and SOX2

DIOPT Version :9

Sequence 1:NP_001286801.1 Gene:Sox14 / 37822 FlyBaseID:FBgn0005612 Length:669 Species:Drosophila melanogaster
Sequence 2:NP_003097.1 Gene:SOX2 / 6657 HGNCID:11195 Length:317 Species:Homo sapiens


Alignment Length:299 Identity:93/299 - (31%)
Similarity:139/299 - (46%) Gaps:63/299 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 KKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLR 244
            :|:||..:|||||||||||:.:|||:.:..|.:||:||||.||..|:|||:.:|:|:|.||::||
Human    34 QKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLR 98

  Fly   245 KLHMIEYPNYKYRPQK---------KQTRSPGSLKP-------------------NQDADGCEAR 281
            .|||.|:|:|||||::         |.|...|.|.|                   ||..|.....
Human    99 ALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHM 163

  Fly   282 NDTTNNNNSLTT----------LAINGTTTAGRKSKRSTSTCQ--SGSASKRLRNDSGDTSSKPK 334
            |..:|.:.|:..          |..:|........:...|..|  |.::|:...|.|      |.
Human   164 NGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGS------PT 222

  Fly   335 YEVKMESAEQLNSADIILPSADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSEV 399
            |.:   |..|..:..:.|.|..:::..::|...|:.|.|:       ||.   .|.::.: |.::
Human   223 YSM---SYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSS-------HSR---APCQAGD-LRDM 273

  Fly   400 VNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMDN 438
            ::.:||   |.........|.|..|||.||.|..|...|
Human   274 ISMYLP---GAEVPEPAAPSRLHMSQHYQSGPVPGTAIN 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox14NP_001286801.1 SOX-TCF_HMG-box 186..257 CDD:238684 41/70 (59%)
SOX2NP_003097.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43 3/8 (38%)
SOX-TCF_HMG-box 40..111 CDD:238684 41/70 (59%)
SOXp 110..200 CDD:315092 16/89 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..266 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 297..317 6/13 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148497
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.840

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