DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and sox12

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001025449.1	Gene:	sox12 / 562381	ZFINID:	ZDB-GENE-040724-33	Length:	355	Species:	Danio rerio

Alignment Length:	429	Identity:	124/429 - (28%)
Similarity:	183/429 - (42%)	Gaps:	115/429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 THTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKH 182
            ||.:|         |.||     |:|..|:.:.:...|.:.|||  .||.|....:.      |.
Zfish     6 THKYS---------SVMD-----SNSSREVFVGLAAEDDAEVFG--HVPSNKDPNWC------KT 48

  Fly   183 SPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRKLH 247
            ..|||||||||||||||:|||||.|:.||:|||||||.||:||:||...:|.|:|.|||:||..|
Zfish    49 PTGHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGKRWKLLPDYEKIPFIKEAERLRLKH 113

  Fly   248 MIEYPNYKYRPQKKQTRSP----GSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKR 308
            |.:||:|||||:||...|.    |...|.:.:.....|:              :|.:..|.|.|.
Zfish   114 MADYPDYKYRPRKKSKGSTPVKLGEKLPMKSSKPLPGRS--------------SGLSCKGLKIKP 164

  Fly   309 STSTCQSGSASKRLRNDSGDTSSKPKYEVKMESA-----EQLNSADIILPSADNLISYQSSEYLP 368
            ::|..:...:|.:.::.|...|.....:|.:||.     ::..|:..:|   ....:.||.:..|
Zfish   165 ASSKHKMNFSSNKYKSYSESMSDDDTMDVNLESPVTQQDDRNTSSHFVL---HQQATVQSEDQQP 226

  Fly   369 L------------STLSNADCDEKLHSELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSL 421
            :            |::.:...|.:..:...|...|.|.:.|                   |.||.
Zfish   227 IPELRVKVPISQTSSIQSLSSDSECQAFPESTTSEPRGSTS-------------------GRSST 272

  Fly   422 TQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLN 486
            ..|..:.|..::...|           |||.||:                 |.:.|:|:   |::
Zfish   273 PTSTSSSSLVSSACSD-----------EELDEEL-----------------LHIISNSM---PMD 306

  Fly   487 EPVFDSEDNIVNDANLHSASH-QIPPY-VPDSHDCFAED 523
            ....|.:....| ||  |.|| ..|.| .|:.::..:.|
Zfish   307 CSTLDKDFEAFN-AN--SGSHFDFPDYCTPEVNEMISGD 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	49/70 (70%)
sox12	NP_001025449.1	SOX-TCF_HMG-box	52..123	CDD:238684	49/70 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582379
Domainoid	1	1.000	109	1.000	Domainoid score	I6276
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm25639
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870