DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and pdlim3b

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_005157291.1	Gene:	pdlim3b / 561865	ZFINID:	ZDB-GENE-060130-104	Length:	332	Species:	Danio rerio

Alignment Length:	279	Identity:	64/279 - (22%)
Similarity:	105/279 - (37%)	Gaps:	59/279 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTKKHSPGHIKRPMNA 193
            |:...:||   |:..|..::   .|.|.:......||     ||.|.|:|... .||.|...:..
Zfish     2 PQNVVLDG---PAPWGFRLS---GGKDFNQPLTITRV-----TPGSKASRVNL-CPGDIILSIQG 54

  Fly   194 F----MVWSQMERRKICERTPDLHNAEISKELGRRW--QLLSKDDKQPYII--EAEKLRKLHMIE 250
            .    |..::.: ..|.:.|..|. .:|.:...:.|  |::.:....|:.|  ||||    ..|:
Zfish    55 VSTDGMTHAEAQ-NNIKDSTNQLF-LKIERPETKIWSPQVIEEGKVNPFKINLEAEK----QDID 113

  Fly   251 YPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTTAGRKSKRSTSTCQS 315
            |..:|:..:.|...|            ...|:|:|:.     ||..|....||     :.||..|
Zfish   114 YFEHKFNVRPKPFTS------------ASQRSDSTSQ-----TLMGNVAQMAG-----TPSTAHS 156

  Fly   316 GSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSE-YLPLSTLSNADCDE 379
            ...:..:...|.|..|....:.:|.:..:..|     ||:..|.|.:.|. |..|.     |.:|
Zfish   157 VQYNSPVALYSADNVSNTLQQAQMSTVVRQAS-----PSSKPLTSIEDSHVYRMLQ-----DANE 211

  Fly   380 KLHSELSSGPLESRENLSE 398
            :.|....||..::.::..|
Zfish   212 QPHEPRQSGSFKALQDYVE 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	17/78 (22%)
pdlim3b	XP_005157291.1	PDZ_signaling	2..81	CDD:238492	21/92 (23%)
		DUF4749	156..232	CDD:292558	19/85 (22%)
		LIM_ALP	262..314	CDD:188834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900