DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and sox9

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001016853.1	Gene:	sox9 / 549607	XenbaseID:	XB-GENE-1034769	Length:	482	Species:	Xenopus tropicalis

Alignment Length:	673	Identity:	137/673 - (20%)
Similarity:	213/673 - (31%)	Gaps:	304/673 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPPF-----------SPSPSPASSPSPAPAQTPGAQKTQSQAAITHPAAVASPSAPVAAAAPKTP 106
            |.||           |.:|||..|...|.:..|....:.::           .:.|.....||
Frog     4 LDPFMKMTEEQDKCMSGAPSPTMSEDSAGSPCPSGSGSDTE-----------NTRPQENTFPK-- 55

  Fly   107 KTPEPRSTHTHTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSST 171
                               ..|..:.|.:.|:.|......::..:.|.|.:||  ...|.||.|:
Frog    56 -------------------GDPELKKETEDEKFPVCIREAVSQVLKGYDWTLV--PMPVRVNGSS 99

  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236
                     |..| |:||||||||||:|..|||:.::.|.|||||:||.||:.|:||::.:|:|:
Frog   100 ---------KSKP-HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPF 154

  Fly   237 IIEAEKLRKLHMIEYPNYKYRPQKKQTRSPGSLKPNQDADGCEARNDTTNNNNSLTTLAINGTTT 301
            :.|||:||..|..::|:|||:|:::::...|.   ::..||.|..:.:.|
Frog   155 VEEAERLRIQHKKDHPDYKYQPRRRKSVKNGQ---SEQEDGAEQTHISPN--------------- 201

  Fly   302 AGRKSKRSTSTCQSGSASKRLRNDSGDTSSKPKYEVKMESAEQLNSADIILPSADNLISYQSSEY 366
                           :..|.|:.||..::|         |..:::|     |..
Frog   202 ---------------AIFKALQADSPHSAS---------SMSEVHS-----PGE----------- 226

  Fly   367 LPLSTLSNADCDEKLHSELSSGPLESRENLSEVVNRFLPLFLGGNEDSQLGVSSLTQSQHNQSDP 431
                           ||..|.||                                      .:.|
Frog   227 ---------------HSGQSQGP--------------------------------------PTPP 238

  Fly   432 TAGLMDNISDISPINDREELTEEVMRYLPYLEVNPSSDGLTLKVESSSLLGKPLNEPVFDSEDNI 496
            |.                          |..:|.|....|..:       |:||.|
Frog   239 TT--------------------------PKTDVQPGKPDLKRE-------GRPLQE--------- 261

  Fly   497 VNDANLHSASHQIPPYVPDSHDCFAEDCGGDSSSHQV---------EFEVVRPQTVTMTMTCTLP 552
                     |.:.||::.     |.:...|:.||..:         ||:...|           |
Frog   262 ---------SGRQPPHID-----FRDVDIGELSSEVISTIETFDVNEFDQYLP-----------P 301

  Fly   553 YGGPDAGHTTFQAD-----DFNAIPSA-------------------------------AEDSECS 581
            .|.|..|.|  ||.     ..|:.|||                               :|.|:..
Frog   302 NGHPGVGST--QAPYTGSYGINSTPSATPGAGPAWMSKQQQQQQQQPQPPQHSLSTINSEQSQSQ 364

  Fly   582 ----ILTTSNSP-------------QIGFNGSSFVEADAIGSTCTYAQQDYTGSVIETHNDLNYA 629
                |.|...||             |:.::..:.....:...|.|.||.|||    |.....:|.
Frog   365 QRTHIKTEQLSPSHYSDQQQQHSPQQLNYSSFNLQHYSSSYPTITRAQYDYT----EHQGSNSYY 425

  Fly   630 AH---DNNGALLAYTFEDLPPQP 649
            :|   .|:|....:::.:...:|
Frog   426 SHASGQNSGLYSNFSYMNPSQRP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	39/70 (56%)
sox9	NP_001016853.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66		15/93 (16%)
		Sox_N	22..94	CDD:403592	17/105 (16%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P48436	63..103		12/50 (24%)
		PQA. /evidence=ECO:0000250\|UniProtKB:P48436	63..103		12/50 (24%)
		SOX-TCF_HMG-box	104..174	CDD:238684	38/69 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..274		40/280 (14%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P48436	224..308		29/214 (14%)
		9aaTAD 1. /evidence=ECO:0000250\|UniProtKB:P48436	276..285		3/8 (38%)
		9aaTAD 2. /evidence=ECO:0000250\|UniProtKB:P48436	291..299		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..395		20/112 (18%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P48436	366..482		18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..482		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910