DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox14 and SOX18

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_060889.1	Gene:	SOX18 / 54345	HGNCID:	11194	Length:	384	Species:	Homo sapiens

Alignment Length:	222	Identity:	77/222 - (34%)
Similarity:	110/222 - (49%)	Gaps:	62/222 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SPSPSPASSPSPAP---AQTPG---AQKTQSQAAITHPAAVASPSAPVAAAAPKTPKTPEPRSTH 115
            ||....|....||.   |..||   |..|:..||  .|||:|:|:||   |:|.:|:...||
Human     4 SPPGYGAQDDPPARRDCAWAPGHGAAADTRGLAA--GPAALAAPAAP---ASPPSPQRSPPR--- 60

  Fly   116 THTHTHSQHFSPPPRESEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTPYSDATRTK 180
                      ||.|....:    ||:..|....                         :|.:|
Human    61 ----------SPEPGRYGL----SPAGRGERQA-------------------------ADESR-- 84

  Fly   181 KHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPYIIEAEKLRK 245
                  |:|||||||||::.||:::.::.||||||.:||.||:.|:.|:..:|:|::.|||:||.
Human    85 ------IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRV 143

  Fly   246 LHMIEYPNYKYRP-QKKQTRSPGSLKP 271
            .|:.::||||||| :|||.|....|:|
Human   144 QHLRDHPNYKYRPRRKKQARKARRLEP 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	36/70 (51%)
SOX18	NP_060889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		33/138 (24%)
		SOX-TCF_HMG-box	84..155	CDD:238684	37/78 (47%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	87..100		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	111..123		7/11 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..218		13/25 (52%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	166..231		2/5 (40%)
		Sox_C_TAD	193..382	CDD:288887
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870