DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox14 and Synpo2

DIOPT Version :9

Sequence 1:	NP_001286801.1	Gene:	Sox14 / 37822	FlyBaseID:	FBgn0005612	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001178892.1	Gene:	Synpo2 / 499702	RGDID:	1564779	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	114/617 - (18%)
Similarity:	193/617 - (31%)	Gaps:	184/617 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TEPPLSLRPGTVPTVPATTPARPATITIQRRHPAPKADSTPHTLPPFSPSPSPASSPSPAPAQTP 74
            |.||::.:| .|.|..::.|..|.:                   |.:||..:||..|:.:....|
  Rat   749 TPPPVAPKP-AVKTSSSSQPVAPVS-------------------PVWSPGVAPAQGPAFSTTNPP 793

  Fly    75 GAQKTQSQAAITHPAAVASPSAPVAA---AAP-KTPK--------TPEPRSTHTHTHTHSQHFSP 127
            ...:..:.::|........|:.|.:|   |.| |.|:        ||:|.:.....:........
  Rat   794 NPPQVTAVSSIKIAQPTCPPARPASALNLAGPFKGPQAAVVSHNYTPKPSAPTPLVNAAPAGAGG 858

  Fly   128 PPRE-SEMDGERSPSHSGHEMTLSMDGIDSSLVFGSARVPVNSSTP-------YSDATRTKK--- 181
            |..| ..|.|:.:...:..:..:....:||..| .:..|...|.||       ||...|...
  Rat   859 PSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTV-QAHTVRAQSPTPSLPASWKYSSNVRAPPPVA 922

  Fly   182 ----HSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRR-WQLLSKDDKQPYIIEAE 241
                |||.:   |:.|           |..:.|....::.||:.|:: ...|.....|||.:.|
  Rat   923 YNPIHSPSY---PLAA-----------IKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNA- 972

  Fly   242 KLRKLHMIEYPNYKYRPQKKQTRSPGSLKP--NQDADGCEARNDTTNNNNSLTTLAINGTTTAGR 304
               .|...:.|:.|....:|.|....|:.|  .|.....:|...:..|..:.:..::...|:...
  Rat   973 ---SLFTFQPPDSKDGLPQKSTVKVSSVAPAMKQALPPRQADIGSPTNAKASSVYSVPAYTSQPN 1034

  Fly   305 KSKRSTSTCQSG--------SASKRLRNDSGDTSSKPKYEVKMESAE-QLNSADIILP------- 353
            ....:||...:.        |..:...:.|...:.:||:..|..... |.|...:.||
  Rat  1035 FFAEATSPVSASPVPVSVPTSPKQETTSTSYFVAPRPKFSAKKSGVTVQENWRSLSLPGRAAPPI 1099

  Fly   354 -SADNLISYQSSEYLPLSTLSNADCDEKLHSELSSGPLESRENLSEVVNRFLP------------ 405
             ||...:...:..|....||.    .||.:...:.....::..|..|...|.|
  Rat  1100 MSAPPWLCQPAYSYSSKPTLE----QEKANKRPTPWEAAAKSPLGLVDEAFRPRNIEESIVANVV 1160

  Fly   406 ------LFLGGNEDSQLGVSSLTQSQHNQSDPTAGLMDNISDISPINDREELTEEVMRYLPYLEV 464
                  :|.|..||.:..:|.:.|:|.....              .::|.|.
  Rat  1161 SAARRKVFAGSQEDWKERLSFVPQTQKTSMS--------------FSERREY------------- 1198

  Fly   465 NPSSDGLTLKVESSSLLGKPLNEPVFDSEDNIVNDANLHSASHQI----PPYVPDSHDCFAEDCG 525
                                          |:.:..|.|.:||.:    .|||     |:.::..
  Rat  1199 ------------------------------NVPSPVNSHVSSHSLYSSQLPYV-----CYRKESR 1228

  Fly   526 GDSSSHQVEFEVVRPQTVTMTMTCTLPYGGPD 557
            .|..:..::         |.:..| ||.||.|
  Rat  1229 NDLKAMSMD---------TRSEYC-LPLGGYD 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox14	NP_001286801.1	SOX-TCF_HMG-box	186..257	CDD:238684	15/71 (21%)
Synpo2	NP_001178892.1	Interaction with VPS18. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	1..174
		PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..363
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q91YE8	392..400
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	477..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..576
		F-actin binding. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	530..658
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	554..560
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..703
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	602..809		16/79 (20%)
		Interaction with BAG3. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	610..621
		PPPY motif. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	614..617
		Atrophin-1	<651..1101	CDD:331285	77/390 (20%)
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..922		40/193 (21%)
		F-actin bundling activity. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..914		39/185 (21%)
		F-actin binding. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..801		15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..799		15/69 (22%)
		Actin binding. /evidence=ECO:0000250\|UniProtKB:Q91YE8	745..898		34/169 (20%)
		Interaction with FLNC. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	808..1153		72/367 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..868		6/34 (18%)
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	899..1153		54/275 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..957		6/34 (18%)
		Interaction with ZYX. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	999..1018		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900